| Objective:To observe the effect of Suhuang zhike capsule (method of dispelling wind and relieving spasm) in treatment of cough variant asthma (CVA wind cough), the safety of clinical effectiveness.Methods:This paper collected a total of 60 patients, collected during the September to 2012-2013 in accordance with the standards of Chinese medicine outpatient diagnosis of lung disease in China-Japan Friendship Hospital Beijing Chinese Medicine Hospital of traditional Chinese medicine traditional Chinese medicine lung disease in Department of respiration, Xuanwu Hospital of traditional Chinese medicine traditional Chinese medicine outpatient department of respiration diagnosis in September:Western medicine:cough variant asthma; TCM: wind cough, "wind heat invading lung, airway spasm syndrome". Using random grouping information, according to the patients into the group of order grouping and release the drug. The treatment group of 40 cases, given the Chinese medicine of Suhuang Zhike capsule,3 times daily,3 capsules each time, a total of 28 days of treatment; the control group of 20 cases, given (Shah Mette Lo/ fluticasone propionate inhalation),2 times a day, each 1, a total of 1,28 days of treatment. Patients were observed at different time points (1 day (treatment group),7 days,14 days,28 days) of the TCM symptom score (including main symptoms and secondary symptoms and total) and cough visual analogue scale change; the end of 28 days after treatment, the clinical curative effect, statistics of cough in patients with TCM symptoms, patient self-assessment and safety indexes.Statistical analysis of data using SPSS 20 statistical software, using independent t test, rank sum test method for the analysis of measurement data; using the chi square test, Fisher exact probability and non parameter test method for the analysis of count data; the results using a two-sided test, there was statistical significance in P is less than or equal to 0.05.Result:A total of 60 case experimental observation, the control group. A patients due to angina pector is, did not continue to participate in the test, by shedding treatment, including 20 cases of male patients (32.2%),40 cases of female patients (67.8%), after treatment, comparison between the two groups of cough,the total effect:the treatment group markedly effective rate, total effective rate was 57.5%,89.5%, The effective rate of control group, the total effective rate were 63.2%,78.9%, two group of curative effect comparison, the statistical analysis, no significant difference (P>0.05); TCM syndrome total curative effect:the treatment group markedly effective rate and the total effective rate was 70% and 97.5%, the effective rate of control group, the total effective rate was 73.6% and 100%, the comparison between the two groups was statistically significant (P>0.05); The total score of TCM symptoms:two groups after the treatment of the integral than before treatment were significantly decreased (P<0.05), but no significant difference between the two groups (P>0.05); the two groups before and after treatment comparison of eosinophil count, IgE count level had no significant difference (P>0.05); In two groups before treatment of bronchial provocation test were positive, the treatment group and the control group negative rates were 25%and 31.6%, between the two groups by statistical treatment negative rate comparison, no significant differences were observed in the two groups (P>0.05); in cough frequency, cough, pharyngeal itching, shortness of breath and cough. The recovery rate. By contrast found no significant differences between the two groups (P>0.05);Safety evaluation:the experimental group and the control group before and after treatment in patients with clinical basic examination data, statistically, there was no significant difference.Adverse events:During the period of observation group incidence of adverse events was 2.5%(1 cases):nausea in patients after taking medicine, vomit, ask the patient to take the medication of patients after reduction no nausea, considered not a drug, patients did not exit and continue to participate in the test to the end. The control group had no adverse events, adverse events rate was 0%..Conclusion:1. Suhuangzhike capsule in the treatment of cough variant asthma with Sere tide in the curative effect, two cases showed no significant diffrence compared, Suhuang Zhike capsule is effective in the treatment of cough variant asthma.2.cough variant asthma because of its clinical an if estations, and traditional Chinese medicine "wind cough" link, in the treatment of bite Shufeng Xuanfei cough, relieving method.3. Traditional Chinese medicine on the understanding of wind syndrome are divided in to two kinds:endogenous wind and wind, from Suhuang Zhike capsule drug can be launched anti wind there is.4. Both the pathogenic wind wonder inside or outside, cold temperature dispersing the powder charge with no obvious bias, cold temperature, and characterized with Xin Ping, "because of the wind, Xin Ping would cure ".5.use of Suhuang Zhike capsule as a quantitative method on behalf of dispelling wind and relieving spasm, clinical observation, on the basis of the content of effective components of drugs has the advantages of controllable can be done for every patient standard, the disadvantage is lost the individualized treatment of dialectical addition and subtraction for each patient, this is the advantage of traditional Chinese medicine, also is a difficulty it is difficult to study the standard.6. Through the symptom score of traditional Chinese medicine, the TCM Syndrome Evaluation in scientific research evaluation system standardized by integral quantization table, TCM syndrome, which is a quantitative standard, more objective to evaluate the therapeutic effect of traditional Chinese medicine.In a word, Suhuang Zhike capsules in the treatment of cough variant asthma with Sere tide effect, and good patient compliance, research methods have certain innovation, the prescriptions of theoretical innovation for its originality. |
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