Clinical Retrospective Analysis Of TCM Syndromes Of 82 Cases Of Primary Sjogren 's Syndrome

Objective:To review the characteristics and relevance of different TCM syndromes and lab text indexes of PSS, thus providing a reference for indexing syndrome classification in TCM.Method:A study was undertaken alongside a self-designed questionnaire. Records of82in-patients and outpatients diagnosed primarily PSS were collected and arranged to record basic information, symptoms, signs and lab text indexes and to be classified in four categories of yin deficiency and blood stasis, qi-yin deficiency, yin deficiency and heat toxicity, yin deficiency of liver and kidney. Statistical analysis used SPSS (versionl7.0)Result:1The distribution of dominate syndromes is yin deficiency and blood stasis (YDBS)>qi-yin deficiency (QYD)>yin deficiency and heat toxicity (YDHT)>yin deficiency of liver and kidney (YDLK)2There is no significant difference in initiating age, age group and duration in the four kinds of syndromes.(P>0.05)3Comparing the symptoms among the four syndromes, YDHT presents more joints pain than other groups and QYD presents more fatigue than other groups, which are statistically significant (P<0.05). Comparing the signs among the four syndromes, YDHT presents more parotid glands enlargement than other groups and YDBS presents more oral ulcer than other groups, which are statistically significant(P<0.05).4Yin deficiency and blood stasis ranks the first in scoring signs of TCM which is significantly different.(P<0.05)5There are36patients presenting with multiple-organ damage (43.9%), of which yin deficiency and blood stasis syndrome is the most frequent, no significant difference there(P>0.05).6Compard with QYD, ESR of YDBS changes more distinctly while CRP of YDHT changes more distinctly; compared with YDHT, RF of YDBS changes more distinctly (P<0.005). Comparing white cells, red cells and blood platelet between groups are no significant different (P>0.05). The mean value of IgA and IgM are both in the normal range and that of IgG is higher than normal. And the differences between groups are not significantly different (P>0.05). The order of the mean value is YDBS>YDHT>QYD>YDLK.7Among the four syndromes,67(81.7%) anti-ANA antibody positive cases Are more than both54(65.9%)anti-SSA antibody cases and39(47.6%) anti-SSB antibody positive cases. Compared with YDLK, anti-SSA antibody of YDBS has a more positivity (P<0.05). The descending order of the positivity is YDBS>YDHT>QYD>YDLK. Compared with YDLK, anti-SSB antibody of QYD has a more positivity (P<0.05). The descending order of the positivity is YDLK>YDBS>YDHT>QYD. The comparison of Anti-ANA antibody between syndrome groups has no significant difference (P>0.05). and anti-SSA antibody is highly positive in multiple-organ damage group significantly different (P<0.05). The descending order of the positivity is YDHT>QYD>YDBS>YDLK.8The positivity of anti-SSA is higher in multiple-organ damage group, which is significantly different(P<0.05).Conclusion:1Syndrome differentiation of TCM of PSS has no connection with patients age, duration of disease and patients sex.2The four different syndromes present with different focused clinical manifestation. YDBS is the most common type with a more complicated patients’condition.3The lab indexs change with different extent in different syndrome group.