Correlation Between Serum High - Sensitivity C - Reactive Protein And Ankle - Brachial Index And Severity Of Coronary Artery Disease In Patients With Coronary Heart Disease

The Correlation Analysis for the Serum High-sensitivity C-Reactive Protein Levels and Angiographic Severity of Coronary Artery DiseaseObjectives:High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation that predicts cardiovascular events in patients of coronary artery disease (CAD). Our objective was to evaluate the correlation between serum levels of hs-CRP and the angiographic severity of coronary lesion.Methods:Total 1594 consecutive hospitalized patients suspected CAD were enrolled. The serum level of hs-CRP and coronary angiography were performed in all participants. CAD was excluded when there was no angiography confirmed stenosis or stenosis less than 50%. The Spearman partial correlation analysis was used to evaluate the correlation between hs-CRP and severity of coronary artery disease, which was determined by the number of stenotic vessels and the Gensini score.Results:The serum hs-CRP was significantly higher (2.03 mg/dl vs 1.63 mg/dl, P<0.001) in patients with CAD compared with nonCAG. The hs-CRP levels increased significantly with the increase of the number of the stenotic vessels and Gensini score. The increased serum hs-CRP were associated with Gensini score, even after the adjustment of confounding factors (P=0.006).Conclusions:For patients suspected CAD,The ABI could be a potential parameter to predict the CAD and the severity of coronary artery stenosis.The Correlation Analysis for Ankle-Brachial Index and the Angiographic Severity of Coronary Artery DiseaseObjectives:To determine the correlation between ankle-brachial index (ABI) and the angiographic severity of coronary artery disease (CAD).Methods:Total 837 consecutive hospitalized patients suspected CAD were enrolled. All patients underwent coronary artery angiography and ABI measurements. The relationship between ABI and the severity of CAD, which was determined by the number of stenotic vessels and the Gensini score, was evaluated.Results:Of the included patients,553 male and 284 female, with an average age of 59.31±9.85. The prevalence of triple vessel disease and left main lesion were significantly higher in ABI≤0.9 groups compared with patients of ABI> 0.9 (60.3% vs. 30.1%,P=0.001). There was a negative correlation between the ABI and the Gensini score, even after the adjustment of confounding factors such as age, smoking status, blood glucose, serum uric acid, triglyceride and high-sensitive c-reactive protein(r=0.094, P=0.007)Conclusions:The ABI could be a useful method in assessing the severity of coronary artery stenosis in patients suspected CAD.