Study On The Effect Of Maduramicin To The Broiler Immunologic Function

An experiment was conducted with 4×1 factorial design to study the effect of dietary maduramicin on immunologic function of broilers. 200 day-old healthy TieJiaoMa broilers with an equal weight were assigned to 4 groups with 5 replicates at random, each having 10 chicks. The broilers were reared in cages. The house was controlled in constant temperature and natural exposure. The broilers were allowed accessing to the food and water at liberty. In trial, the broilers were fed with a basal corn-soybean meal diet supplemented with 0, 5.0, 7.5 mg/kg and 10.0 mg/kg maduramicin for 4 weeks, according to the secure dose and lowest toxicity dose in existence. The trial was carried through when the broilers were 11 days old and persisted 7 weeks. Finally, the results of the trial were received, by observing or determining the symptom, growth performance, indexes of immune organ, histopathology change of immune organ, percentage of the erythrocyte complement receptor rosette, percentage of erythrocyte immune compound rosette, lymphocyte transformation, antibody titer of the ND and lymphocyte cycle of the spleen. The experiment results indicated that: 1. The growth performance and immunologic function of the TieJiaoMa broilers were advanced in the former 3 weeks of the trial and then were checked gently by 5.0mg/kg maduramicin when compared with the control group. 2. The forage availability of the TieJiaoMa broilers was depressed in 1^st week of the trial and the immunologic function of the TieJiaoMa broilers was checked from 3^rd to 5^th weeks of the trial by 7.5 mg/kg maduramicin when compared with the control group. 3. The forage availability of the TieJiaoMa broilers was depressed in 1^st week of the trial and the immunologic function of the TieJiaoMa broilers was checked from 2^nd to 5^th weeks of the trial by 10.0 mg/kg maduramicin when compared with the control group. 4. It was safety to feed the TieJiaoMa broilers with a diet supplemented with 5.0mg/kg maduramicin for 3 weeks, and the TieJiaoMa broilers could be poisoned when fed with a diet supplemented with 7.5-10.0mg/kg maduramicin, but there was no typical toxic symptom. 5. The depressant...