Studies On The Alkaloids Of Magnolia Officinalis

Magnolia officinalis subsp.biloba(Reh.et Wils) Law is the dry bark of stalk and branch of the Magnolia. It grows widely in China and it is one of the most famous and precious Chinese traditional medicine. Magnolia officinalis(Houpu) is warm in nature, bitter and acrid flavor. It can warm the middle warmer, promote the flow of qi, eliminate dampness, remove food stagnation and so on. Houpu is very important in the clinical application, it is usually used to treat eliminating inflammation, sterilization, turgescent chest and abdomen, intestinal obstruction, eliminating phlegm and gasp etc..The crude alkaloids were extracted by strongly acidic cationic exchange resin and monomer compound was isolated and purified by silica gel column chromatography and chromatotron. Sixteen compounds have been isolated from the bark of Magnolia officinalis subsp.biloba(Reh.et Wils) Law which is from Du Jiangyan in Sichuan province. Thirteen compounds were identified by NMR, MS, TLC etc. They are magnolol, honokiol and eleven isoquinoline alkaloids: liriodenine,roem-erine, lirinidine, lysicamine, reticuline, anonaine, isosalsoline, N-methylisosal-soline, asimilobine, N-nornuciferine, nornantenine. There are eight aporphine alkaloids, one benzylisoquinoline alkaloid and two simple isoquinoline alkaloids. Roemerine, lirinidine, lysicamine, isosalsoline, N-methylisosalsoline, N-nornuciferine, nornantenine were first isolated from the plant.We first systematically study the alkaloidal constituents of the plant Magnolia officinalis subsp.biloba(Reh.et Wils) in Sichuan province. It is not only important to improve the nature pharmaceutical chemistry, but also advantageous to explore resources of Houpu medicinal plant in China.