Effect Of Sodium Bicarbonate On The Pharmacokinetics Of Sulfachlorpyraizine In Broilers

The pharmacokinetics of sulfachlorpyrazine (SPZ) were studied following single intravenous (i.v.) (25 mg/kg b.w.), oral administration (50 mg/kg b.w.) and after taking sodium bicarbonate (50 mg/kg b.w.), p.o. administration (50 mg/kg b.w.) of the drug in healthy broilers. The study was on what did sodium bicarbonate affect the pharmacokinetics of sulfachlorpyraizine in broilers.Thirty healthy broilerss. With body weights of 1.74 to 1.91 kg were randomly divided into 3 equal groups of 10 birds each. Blood samples were collected at different interval (0~48h) after administration of SPZ. SPZ in plasma was extracted and deproteined by methanol. The concentrations in plasma were determined by high performance liquid chromatography (HPLC) with UV detector.The concentration-time data of SPZ in plasma was analyzed with 3p97 computer program. The concentration-time data of SPZ in plasma after single i.v. administration in healthy broilerss were fitted to a two-compartment open model without absorption. The main pharmacokinetic parameters of SPZ in broilers were as follows: t1/2α0.14 h, V(c) 0.35 L/kg, t1/2β7.5 h, Cl(s) 0.083 L/kg/h.The concentration-time data of SPZ in plasma after single oral administration in healthy broilerss were fitted to a one-compartment open model with first-order absorption. The main pharmacokinetic parameters of SPZ in broilers were as follows: Ka 0.591 1/h, t1/2ka 1.17 h, V(c) 0.71 L/kg, tmax 3.80 h, Cmax 51.09μg/ml, t1/2ke 8.05h, Cl(s) 0.061(h·L)/kg, AUC 823.04(mg/l)·h, F 137.31%. The concentration-time data of SPZ in plasma after oral administration of sodium bicarbonate and SPZ synchronously in healthy broilers were fitted to a one-compartment open model with first-order absorption. The main pharmacokinetic parameters of SPZ in broilers were as follows: Ka 0.871/h, t1/2ka 0.80 h, V(c) 0.72 L/kg, tmax 2.89h, Cmax 52.91 mg/L, t1/2ke7.50h, Cl(s) 0.067 (h·L)/kg, AUC 747.40%, F 124.68 %.The results of the studies showed that SPZ was widely distributed and eliminated slowly. The oral administration of SPZ was rapidly absorbed. The bioavailability was high by the oral routes. Compared the main pharmacokinetic parameters of single oral administration, the main pharmacokinetic parameters of oral administration of sodium bicarbonate and SPZ were influenced observably (P<0.01). Ka, V(c) and Cl(s)increased significantly, tmax, t1/2ka, AUC, t1/2ke and F declined obviously.