Clinical Prevention And Control Of Mycoplasmal Pneumonia Of Swine With Two Kinds Of Chemotherapeutic Agents

Any species, ages and sexes of swine can be infected by Mycoplasmal Pneumonia of Swine (MPS), especially lactated pig and piglet, secondly pregnant and lactating swine are more sensitive. The disease often spreads quickly and breaks out, it has high ratio of incidence and infection, and it can badly hurt large scale piggery. At the same time, it inspires respiratory syndrome and provides channels for varies of pathogens. So, the control of mycoplasma infection is one of important problems to solve the perplexity of diseases for large size of piggery. At present, the medicament therapy and prevention are principal methods to control this disease. Oxytetracycline is suggested on prevention of the disease because of its high efficacy and cheapness. Compound preparation of enrofloxacin + sulfamonomethoxine injection with union medication expands the antibiogram and reduces the dosage, so it is the prefer choice for the recovery from disease and self-protection of the organism. Therefore, we use oxytetracycline and enrofloxacin + sulfamonomethoxine injection to prevent and treat MPS at clinical test.Oxytetracycline prevention experiment to MPS at clinical test: Choosing 120 same species healthy pork pigs (breastfeed piglets changing to fattening pigs) and randomly separating (from sows with same species, same pregnancy number and nearly same number pigs farrowed) into four experimental and control groups with same feeding condition, replenished 571800u /kg oxytetracycline in feeds of experimental groups gradually, only basic feeds for control groups. Results showed that the incidence of MPS of experimental groups is much lower than that of controls with significant difference (P<0.05), pathological pneumonia records is much lower (P<0.05) and slaughtering weight increases 1.57kg per beast, the ratio of feeds and pork decreases 0.13, the total profit increases 10.73RMB per head compared with controls. We find that supplement of oxytetracycline (571800u /kg) in the feeds can control the MPS effectively, increase the slaughtering weight, decrease the ratio of feeds and pork, decline the rate of incidence and mortality, and raise the economic benefits remarkably.Enrofloxacin + sulfamonomethoxine injection to treat MPS at clinic experiment: In order to confirm the treatment result of Enrofloxacin + sulfamonomethoxine injection to MPS, three different groups of high, middle and low dosage (0.5,0.25,0.125ml/kg) were treated MPS by injection, with four controls, an enrofloxacin injection (0.1ml/kg) group, a sulfamonomethoxine injection(0.5ml/kg) group, a positive infection group and a healthy negative group, and analyzed the results from the clinical symptom, the pneumonia pathological degree as well as the average weight increment. The results showed enrofloxacin + sulfamonomethoxine injection with high, middle and low dosage and enrofloxacin injection are all potent to MPS with significant difference compared with positive control. The effect of enrofloxacin + sulfamonomethoxine injection of high and middle dosage group is better than that of enrofloxacin + sulfamonomethoxine injection of low dosage and enrofloxacin injection group significantly. The effect of sulfamonomethoxine is bad and has no significant difference compared with positive control. So, enrofloxacin + sulfamonomethoxine injection of high and middle dosage is effective to treat MPS. Summing up the weight increment and pneumonia pathological degree, enrofloxacin + sulfamonomethoxine injection of middle dosage is preferable and effective, optimum dosage is 0.25ml/kg, once a day during 3 days.According to above experiment results, the prevention function of oxytetracycline and the treatment function of enrofoxacin + sulfamonomethoxine to MPS at clinical test is scientific and practical.