Avian Influenza Information System Construction

H5N1 viruses were continuously reported from 2003 and caused serious economic loss. Much social attention has been focused on that. Avian Influenza A viruses could directly infect human and mammal. Although avian influenza viruses could not spread among crowd, they had partly been adapted to human and mammal hosts and that could result in pandemics. The differences between the sequences of avian influenza viruses are important and valuable to be studied, especially the molecular characterizations of avian influenza viruses isolated from humans. In order to make the bioinformatical studies on avian influenza more efficient, it is necessary to build an avian influenza information platform.In this article, data from international canonical database ISD and IVR of NCBI were downloaded to build a local database FLU-KEY by Python, CGI technology. Based on this database, a web search system was built using HTML, Python and CGI. Specially, a new search method was developed by which researchers could get and download virus data ( fasta format ) including all six internal proteins.In host transmission section, a method developed by Dr. Kou was used to make a classification machine which can indicate whether the virus could transmit from avian to human. First, wavelet packet decomposition was done on the new virus genome sequence to get the energy quantities. Then KNN method was used to calculate the Euclidean distances and determine whether the virus could transmit from avian to human. Last, this classification machine was combined to the avian influenza information platform by Biopython module and PyWavelets Module of Python.Using this platform, researchers could not only search and download avian influenza data to do bioinformatical research, but also do analysis and prediction to know whether a new virus has the characteristic of host transmission.