| Objective To determine whether FDG-PET could detect gastric carcinomas of the nude mice.Methods A total of 12 nude mice were divided into three groups: Group A (n=4), Group B (n5) and Group C (n=3). Group A and Group B were designed as experimental groups. The nude mice were injecte~ human poorly differentiated gastric adenocarcinoma cells SGC-7901though subcutaneous in the right forearms. Group C was designed as control group. The nude mice were produced chronic granulomatou inflaimiat ion models by foreign body. FDG-PET scans were performe4 when the d iarneters of mass were about 0. 5cm-1.6cm. FDG uptake was semiquartitated by determination the activity per pixel on the region of interest (ROl) curve and the T/NT were calculated after scan.Results FDG-PET detected all the masses. In the same group, the I/NT between spleen and heart did not show statisticat significance (p>0.05), but the T/NT among kidney spleen liver~ between kidney and heart, between liver and heart al I show statisticai significance (p<0.01). The T/NT between experimental groups did not show statistical significance (p>0.05), but the T/N11 of experimental groups was statistical iy higher than control group (p<0.05). All carcinomas exerted intense FDG uptake and showed a high value contrast to normal tissue (p<0.01). All granuIomatous11lesions also exerted intense FDG uptake and show a high value~. contrast to normal tissue (p |
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