Relationship Between Matrix Metalprotenase-2 And Nm23 Expression On Primary Hepatocellular Carcinoma

: AI1STl{At'l'0bjection: we studied lIllllp--2 aIl(l ll11l23 weatller tlley llavecorrelatiOIl f or which one is IIlore illlportaIlt, to prognosis and.lnetastasis of prinlary llepatocel lu lal' carciIloma. MethOds:Smples from 30 patiel1ts oI,erate(l ol1 for llepatoce1lular.carcinoma of IIBsAg posi t ive, who l1ad got 1 iver cirrhosis, werelanalysed by ianunohistocllellIistl'y, 10cases l wIlo suffered from~ POst--lle pat itis ci1.I'Ilosis, as a coIlt 1'ol g1'oup. A11 HCC patientsis II patterIl II stage. Results:1'lle exl)1'ession of mIIlp--2 aIld nm23is negti ve in l0cases colltrol gl'o[lp, TI1e expression of AFP isnegtive too. 30 cases tUIIloul' t issues wel'e tested. AIllollg theal ive group pat ients, expI'ess ioll of nu1Ip--2 is 10 casespositive l 6cases mi 1d posi t ive, lcase negtive, they havesignification between al ive gro[lp a11d control group P wt0. 005. expression of AFP of 1 21 cases is p()sitive, 9cases: negt ive, they l1ave sigIlifica t i()Il l)e1 wee11 al ive group andcontrol group P wt 0. 005. expl'ess ioll of Illl123 is 1 case- [legtive f 6cases mi ld posi t ive, 4cases posi t ive, 6cases strongposit ive. AmoIlg tlle dead gI'o[lps pat\ ipllts, expression of nunp--2is 4cases posi tive, 2caSes Illi l(l I,osi t ive, 7case strong' positive; expression of nm23 is 9(:ases nIi ld positive, 4casespositive .'Ttley Ilave sigl1i fi,cat ioIl correlatiOI1 among the.' expression of nnup--2. AFP and t[lnIOtlr size P<0. 005; They have.... slgnification correlatioIl allloIlg t Ile expression of nm23' AFP' 'and tumour size Pwt0. 005, Tlley llave sigI)ifi cation correlat ionbetween the exprepsion of Illu23. IllIllp--2 aIld AFP P<0. 005, butclinic signification in criticizing the prognosis of HCC . The expressions of both iiimp? and nni23 have correlation to the metastasis of the patients of HCC, who still suffered from liver cirrhosis and HBsAg positive. They have correlation to the tumour size of the patients of HCC too, the result told that if the tumour size is bigger, the patient?s prognosis is poorer.Postgraduate Ding Ha iTutorLi Do Chun...