The Animal Test And A Mathematical Model Of The Peripheral Extra-corporeal Circulation

Accidents happened frequently with the economy developing rapidly. How to resuscitate the patients whose heart beating suddenly stopped, especially the brain resuscitation became one of the hot topics in modern clinic science. For this purpose our group proposed a method for emergency treatments based on membrane artificial lung which set up the peripheral extra-corporeal circulation to help resuscitation. Over 20 dogs were tested in order to examine whether the method was practical or not. It was shown that the method got successful since the dogs could eat, sleep, run and bark two days after operation. But it would cost dearly to sieve the best periphery extra-corporeal circulation and the clinic test was strongly condemned morally. Therefore, the mathematical model became an important supplement of the animal test.In this thesis the author reviewed the history, methods and many applications to the cardiovascular system modeling. It was noted that the Bond Graph theory had been widely used in various kinds of engineering fields and also in cardiovascular system modeling abroad but relatively rear domestically. In this thesis two models of the normal cardiovascular system and the periphery extra-corporeal circulation were introduced. The results of the models showed the reassignment of the blood pressure and flow rate at important organs and provided the additional proofs for the optimization of the periphery extra-corporeal circulation. If the parameters of the dog were adopted the method could also direct the further animal test. Since the parameters played a significant role in the modeling the optimization method was applied to the specific model of the left-coronary flow for the calculation of the parameters. With the optimized parameters, the calculated flow rate curve of the left coronary agreed well with the standard curve in the reference book.