| Medical nutrition therapy (MNT) is integral to total diabetes care and management, and is one of the most challenging aspects of diabetes care, MNT for type 2 diabetes should be individualized with consideration given to usual eating habits and other lifestyle factors, namely, nutrition recommendations should be developed to meet treatment goals and desired outcomes; while, nutrition prescription should be applicable and acceptable by patients to large extend.After 1990's, some of computer systems had been invented in Western countries to standardize nutrition therapy for diabetes mellitus. There are various ethnic food and eating habits. It is not appropriate to bring in the ready-made software and apply directly on Chinese type 2 diabetes. Therefore, There is a pressing need to develop software, which is suitable for Chinese type 2 diabetes. A software, named after "Diabetes Diet Advisor (PC-DR version 1.0) has been developed by Dr. Gu Wei, a professor of The 2nd Affiliated Hospital of Zhejiang University College of Medicine. The database provides a rational and guidance for recommendations and proposals in making meal plan and recipe for Chinese type 2 diabetes. The purpose of this study is to determine the effect of this computer -assisted dietary therapy on Chinese type 2 diabetes.In our study, 88 and 62 patients with type 2 diabetes were assigned to experimentalgroup (group 1) and control group (group 2). In group 1,88 NIDDM (34 men, 54 women; mean age:62.4+8.28y),whose meal recipes were calculated by the diabetes software, in group 2, 62 NIDDM (27men ,35women;mean age:59.8?10.97y),whose dietary regime were controlled in fixed carbohydrate content. Before dietary therapy, both groups were measured by the following baseline data: fasting blood glucose (FBG), 2-hr postprandial blood glucose (PEG), glycated hemoglobin (GHb), total cholesterol (TC), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-C), triglyceride (TG), microabluminuria ((UAER), LP (a)-lipoprotein, body mass index (BMI), systolic pressure (SBP) and diastolic pressure (DBF). Then the patients of two groups were managed by respective dietary therapy methods. All patients were followed up biweekly interval .At 2,4,6 weeks after entry, FBG and PBG were measured. After 8 weeks of each diet regime. All subjects were measured the same experimental data as the predict described previously. The results showed that: (1) FBG, PBG, GHB, TC, TG, HDL-C and BMI in group 1 were significantly less than that of group 2(P<0.05), whereas no difference between two groups in HDL-C, LP (a), UAER, SBP, DBF were found (p>0.05). (2) Those patients in the group 1, significant decrease achieved on their FBG, PBG, GHB, TG, BMI, UAER, SBP and DBF after 8 weeks dietary therapy. And no change was shown in LDL-C, HDL-C and UA. Whereas those patients in the group 2, significant decrease was observed on their FBG, PBG, and DBF. After 8 weeks dietary regime and no change was shown in GHb> TG > BMK UAERx SBP, HDL-C> LDL-C. (3) In the group l,multivariate analyses revealed that both FBG and PBG at 2,4,6,8weeks are significantly declined compared with baseline, no differences was shown among the glucose concentrations (both FBG and PBG) at 2,4,6,8 weeks, and the minimum of fasting plasma glucose concentrations and 2-hr postprandial plasma glucose were at 4 weeks. In the group 2,the decrease in FBS was significantly different from that observedbefore initiation of diet therapy, which was only at 2 weeks. Whereas FBS values at 4,6,8weeks did not change significantly from predict; PBS values were significantly decreased at 2,4 weeks compared with the baseline, and it was not significantly different 6,8 weeks from that observed at baseline, it's minimum was at 2 weeks. (4) 25 patients(28.41%) in group 1 and 6 patients (9.68%)in-group 2 reduced their dosage of hypoglycemic agents or stopped their hypoglycemic agents using. Differences from two groups are significant. Conclusion:1 The clinical applications of the Dietary Diet Advisor (PC-DR version 1.0) for Chinese...
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