Effect Of Pulmonary Surfactant On Pulmonary Vascular Permeability In Asthma

[Backgroundj Asthma is a chronic pulmonary inflammatory disease that affects seriously patients-health and involves a series of inflammatory cells and mediators. Recent data indicated that there was marked inactivation or dysfunction of pulmonary surfactant (PS) that resulted from the increased permeability of bronchial epithelia and vascular endotheliar in an asthma attack. It was also proved that exogenous PS could alleviate asthma attack. [Obiective] This study was designed to examine the change of pulmonary vascular permeability and the effect of PS on it in order to find the pathogenesis for PS given prophylactically and therapeutically in asthma. [Methods] A asthmatic model of guinea pigs was set up. We used modified evans blue fluorimetry for determination of pulmonary vascular permeability in normal, immunized, asthmatic guinea pig groups and to which PS was given before or after a challenge. [Resuits] (1) The pulmonary vascular permeability of asthmatic guinea pigs was higher than that of normal(PO.05) (3) The pulmonary vascular permeability of guinea pigs in group that PS was given prophylactically was lower than that of asthmatic guinea pigs(P