A Study On The Treatment Of Osteoarthritis With Tonifying Kidney And Strengthening Bone Herbs

OtoCTM stUdy on tile n3echltism of beatinent of Os[eoaI-thrihs ''iti1 -Io1hf};ingkidrie}' and Strellgh1ening Bone IIerbs,zeh fOr the inten2al relationship 1o validatelhe tlleo17 of Detennining the condiho11 of il1e bol1e di1d 111arrow and direct tl1e cli11ic\'ork betteL\IETHODS Se1ect the health}' \L1star ratS and OA 111odel of ll1e n1odel ofdetIciency of the klidi1ey ratS as ti1e researcl1 objec.n1e OA model is caused by cudri1ginside co11ateral ligall1ents anterior cruciate 1ig.pos1eTior cruciate 1ig andllledial llleniscus of the left knee and oveq' .-l11e test rats are mi1do1uly sepaIated intO4 guups; ti1e herb treatulent grOuP,U1e Fenbid beati11ent group,ll1e nlodel control poup,iuld ille nornlal coItril grotlp.At llzee tli11e poliltsf2 \\ecks,4 1'eeks,8 \weks afleru'eah31ent respetix'ely; killing the ratS randondy in aseh peup and colleCing h1e tissuessucll as cartilage. s}ro\ia and blwnn in1altwg and observli1g the indexes ofhi stopatho logr, Lilwt ctLire an d bl dri b ioclle nll stiy.RESMS l .the conen of PGE2 in Synovium at arend week,each gnuP PGE2blcreases ob\iously excePt for nomial grOup.The PGE2 of modeI grOU rises higheStmld compared x'iil1 the normal grOuP,the value of P is below 0.05 (P<0.05), the grouPof Fenbid has il1e effat of depressing tire PGE2 foImaon obviouslyAt 8h1 ''eck, inhle group of tomapg kidney herb and the grOuP of Fenbid the reduction of PGE2 isapPrOxinateIy nonnal,and beti1 the herb grouP and the Fenbid group have nosionifiCan difference.2. the level of E2f the grouP of toniforg kidney and Sforngthening bone herbs issignificanly higher than the ones ofmedel and Fenbid.3.the nUInber of blood vessel undr Cartilage' with the process of tiIne the number ofmedel grDup increases gIadually and is significanhy different frOm the normalgrOuny<0.05).At the same tiIn,the herb grouP has significant difference comPardwith noed grouop<0.05), and at 8th week it showes the sazn effect compared Yvih1model grouP O<0.05),4.the lere ofarthrosis cwhlage in model group is not even, the thickness of cartilageis obviously abnonnal,and thefe are some dead drilage celIs too.By lightdricroscope.tve can see the nuclei have the obvious excursion,but under electrOnnhcroscope the cartilage cells show dissolution, the projecting and the membrme ofcells diSaPpearThe cytoplaStS are slur and the nuclei dissolve into twentS,in themodel grouP the nUInber of isogeneous group of cartilage decreases.But in theFenbid grouP,the cAnlage cells have not only the obvious cell death but also the cellhyPerplasia.The cell grOwth shows asyInInetry and comPared with the model grOup hleobvious daInage of Msis talilage aPpears.The daInages include the abnormalbreach ofcwhlage in arthrosis and the abnormal cell hgurplasia.5. The dissolution ofoIganelle and karyotheca in some cartilage cells is observed in thegrOuP oftoniforg kidney and sbengthening bone herbs Under electron nhcroscope, bL1tin moSt of the cartilage cells the orsane1le can keep the inherent confOrmation and tvecan see Inan obese drilage cells.6.At 8th week,in the grOuP of Fenbid the thickness of arthrsis cartilage is slightlylower than the grouP ofmedel,but there is not significan difference.But in the grOuP oftonimpg kidney herbs the thickness of arthrsis Cartilage is aPParentiy higher than ti1egroup of model,the difference is signifiCan(P<0.05).The number of Cartilageisogeneous cells is significanUy different frOm the grouP of modelre<0.05).Under7electron lhicroscoPe the cartilage cells in the group of tonifying kidney herbs cIuster,proliferating and shOwing obesityThe nu!nber of Mlles in cell inczes and thesl1ape of Mi becomes biggerItS creSt becomes wide and the RER exPands.CONCLUSION The herb of Tonihog kidney and hagthening Bone can relaxthe pain of OSteOarthris by edcing the conten of PGE2 in Synovium, ameliOratedle statement of kidney weak of the body Promote the develoPment of blood vessel inmarro\v rn...