Study On The Proliferation Inhibition And Apoptosis Induction In Leukmia Cells Treated By Cholesterol Synthesis Inhibitor Lovastatin

1. Lovastatin inhibits the proliferation and viability in human NB4, IlL- 60, KG-i, 1(562 leukemia cells and primarily cultured cells from patients with leukemia in vitro Objective To study whether lovastatin can inhibit the proliferation and viability in human NB4, HL-60, KG-i, K562 leukemia cells and primarily cultured cells from patients with leukemia. Methods NB4, HL-60, KG-i, K562 cell lines and primarily cultured cells were used for in vitro culture study. Cell proliferation and viability was analyzed by MIT assay and trypan blue exclusion assay. Results (DLOV inhibited NB4, HL-60, KG-i, K562 cells proliferation with the 1C50 of 12.59, 17.16, 51.65, 58.95 jimol/L respectively.? LOV inhibited the proliferation of leukemia primarily cultured cells regardless of the age.. subtype and cell lineage~ peripheral white blood cell~ bone 昺affow blast percentage, etc. 甌he cell viability decreased in four Lovastatin-treated cell lines in a time-dose dependent manner. Conclusion Lovastaiin inhibits the proliferation and viability in NB4, HL-60, KG-i, K562 cell lines and shows the similar effects in the leukemia primarily cultured cells to some degree.