A Development Observation Of Blood Vessel Active Substances On Acute Pulmonary Embolism Caused By Echinococus Granulous Cyst

Abstract Objective To investigate the role of blood vessel active substances, endothelin-1(ET-1),thromboxane B2(TXB2),6-keto-prostaglandF1α(6-k-PGF1α), blood gas analysis, mean arterial pressure(MAP),heart rate,respiration rate, radionuclide pulmonary perfusion imaging, heart and lung pathological changes in acute pulmonary embolism of rabbits caused by echinococus granulous cyst, as well as their significance and correlation. Method An operation was performed for each animal to place a femoral artery catheter and at the meantime a femoral vein catheter for infusion, specimen and data collection. Saline, fresh clear cyst fluid or sand-contained cyst fluid was given to animal in a volume of 2ml/kg through femoral vein catheter. We observed ET-1,TXB2,6-k-PGF1α,PaO2,PaCO2,pH,　MAP ,heart rate, respiration rate, radionuclide pulmonary perfusion imaging, the change of heart and lung pathological. Result All parameters showed no remarkable change in saline group p>0.05). TXB2 and 6-k-PGF1αwere appeared elevated in clear cyst fluid group and sand-contained cyst fluid group(p<0.05), TXB2 /6-k-PGF1α also raised(p<0.05) . PaO2, PaCO2, MAP declined in clear cyst fluid group (p<0.05),While remarkable decline of these four parameters in sand-contained cyst fluid group. radionuclide pulmonary perfusion imaging showed radioactivity of lung weaken or defect. Pathologic histology examination of the lung exhibited ARDS-like changes, while the changes of lung were severer than that of cardiac muscle. Conclusion The effects of sand-contained cyst fluid were severer than that of clear cyst fluid group when cyst fluid get into circulation .It showed that sand-contained cyst fluid played an important role in damage of the lung of acute pulmonary embolism.