Relationship Between Changes Of Nerve Cell -. Neuroglia Cell And Dysfunction Of Central Nervous System With Myasthenia Gravis.

Objective To explore the relationship between changes of nerve celL neuroglia cell and dysfunction of central nervous system (CNS) with myasthenia gravis (MG). Methods The experimental MG model was established by injection of acetylcholine receptor antibody (AChRAb) which was purified from MG serum into the rat cerebral ventricle. While the control group rats was injected with IgG from healthy persons. The changes of nerve cell and neuroglia cell were observed under transmission electron microscope. Results Model rats presented the symptoms and signs that imitated experimental autoimmune myasthenia gravis (EAMG). The apoptotic nerve cell and neuroglia cell were found in the hippocampus and cerebral cortex after intracerebroventricular administration of AChRAb. The apoptotic cell rate in the experimental MG model was significant compared with control group. Dynamic observation: Nerve cell and neuroglia cell have the tendency to apoptosis at the end of 1st week after intracerebroventricular administration of AChRAb; the apoptotic nerve cell and neuroglia cell were found in the hippocampus and cerebral cortex at the end of 2nd week, the apoptotic changes were correlated with the animal's symptom and the time of injection with AChRab. It was significant compared with control group. ConclusionThe results indicated that cerebroventricular administration of AChRab could introduce CNS dysfunction of rats. Nerve cell and neuroglia cell apoptosis were correlated with the animal's symptom and the time of injection with AChRab. The cell apoptosis may play an important role in the pothogeneises of dysfunction of CNS in MG, and with interaction between the nerve cell and neuroglia cell apoptosis would increase the dysfunction of CNS.