The Relationship Between Ang Ⅱ, TGF-β1, PAI-1 And Benign Arteriolar Nephrosclerosis Due To Primary Hypertension

Objective To investigate the roles of AngU ,fibrinolytic activity and transforming growth factor -fil (TGF-f31) in benign arteriolar nephrosclerosis due to primary hypertension.Methods 192 patients of primary hypertension were divided into 3 groups according to the degree of hypertension. In each group , I measured plasma plasminogen activator inhibitor (PAI-1) and urine TGF-fJl levels using ELISA. I also measured plasma Angiotensin E (AnglJ) levels using RIA.Results Each of the three primary hypertension groups had higher levels of PAI-1 and TGF-31 compared with the control group. Group HI had markedly elevated levels of PAI-1 and TGF-J31 compared with the group II , and group II had higher levels than group I . The clinical group had higher levels of PAI-1 and TCF-^l compared with the sub-clinical group. Each of the endings was statistically significant .Conclusion The incidence of benign arteriolar nephrosclerosis due to primary hypertension is related to the degree and the course of hypertension. Abnormalities of fi-brinolytic activity and TGF-J31 levels play an statistically significant role in benign arteriolar nephrosclerosis due to primary hypertension. These abnormalities may be factors contributing to benign arteriolar nephrosclerosis due to primary hypertension .