Relationship Between Hypertensive Myocardial Fibrosis And Angiotensin Ⅱ And Transforming Growth Factor-β₁

Objective: To investigate the changes of serum fibrotic indices , angiotensin II and transforming growth factor- (i| in essential hypertensive patients and to discuss the relationship between myocardial fibrosis and serum angiotensin II and transforming growth factor- β₁ in the left ventricle remodeling. Methods The study was performed in 24 normotensive healthy controls and 60 patients with essential hypertension ,asked history, measured height and weight and blood pressure, determined the value of echocardiographic left ventricular mass(LVM). Left ventricular mass index (LVMI) was obtained by dividing LVM by body surface arcu(BSA). The presence of LVH was established when LVMI was >116 g/m2 for men and >104 g/m2 for women. There were 29 essential hypertensive patients with left ventricular hypertrophy (LVH) and 31 essential hypertensive patients without LVH .Serum procollagen type III(PCIII), laminin (LN) ,hyaluronic acid (HA) and plasma angiotensin II (Ang II ) were measured by radioimmunoassay . The serum concentration of transforming growth factor- β₁ (TGF-li|) was measured by ELISA method. We compared the parameters above mentioned between three groups. The correlations between serum PC III , LN , HA , the plasma Ang II and serum TGF-Bi were analyzed in essential hypertensive patients .Result Serum PCIII,-3-LN, HA and TGF-Bi were significantly different (P<0.01) between hypertensive patients with LVH and those without LVH or healthy subjects. Serum LN and HA were significantly different (P<0.05) between hypertensive patients without LVH and healthy subjects. Plasma Ang II was significantly different (P<0.01) between hypertensive patients and healthy subjects. Serum TGF-Bi and the plasma Angll corrected by history positively correlated with serum PCIII (p<0.05) in the group of hypertensive patients. The plasma Ang 11 corrected by history positively correlated with serum TGF-Bi (p<0.05) in the group of hypertensive patients. Serum TGF-6i and the plasma Ang II did not significantly correlate with serum LN ,HA (p>0.05) in the group of hypertensive patients. Conclusion These measurements of serum PCIII, LN ,HA can reflect myocardial fibrosis development with the occurrence of LVH in essential hypertensive. The TGF-6i and the long-time chronically increased circulating Ang II played an important role in myocardial fibrosis. The serum TGF-Bi may be influenced by the long-time chronically increased circulating Ang II .