A STUDY ON Ki67 GENE EXPRESSION AND ITS SIGNIFICANCE 1N NASOPHARYNGEAL CARCINOMA

Objective To evaluate the significance of Ki67 protein expression in Nasopharyngeal carcinoma(NPC), and the relationship between Ki67 and distance metastasis, Ki67 and Clinical stage, and et al.Methods Immunohistochemical technique was applied to detect Ki67 protein which correlated in cell proliferation expression in 66 NPC patients .Of them, 33 cases with distant metastases and another 33 cases without distant metastases; one case was classified clinical stage â… 1, 8 cases were classified clinical stageâ…¡, 31 cases were classified clinical stage â…¢, 16 cases were classified clinical stage â…£; and 46 cases with cervical lymph nodes metastases and another 20 cases without. Results â‘ The expression of Ki67 in the group with distant0metastases was significant higher than that in the group of without distant metastases (P<0.001). â‘¡The correlation between Ki67 and clinical stage was positive (P<0.05, R=0.268). â‘¢The expression of Ki67 was not related to T stage. â‘£The expression of Ki67 in the cases with cervical lymph nodes metastasis was higher than that of without . However, there was no statistically significant correlation existing between both groups (P=0.160>0.05). Conclusions The increased expression of the Ki67 gene could be correlated to the carcinoma distant metastasis in NPC patients. Alteration of Ki67 protein expression in the tissues of NPC may be related to the clinical stage of NPC The expression of Ki67 may be used as a indicator for evaluating prognosis of NPC .