| Liver transplantation is an increasingly common curative therapeutic solution for patients with end-stage liver disease. Vascular complication of liver transplantation are a major threat to the survival of the graft. Hepatic arterial vascular complications are the most common vascular complication. This study focused on MSCT and investigating the usefulness of multi-slice CT angiography and dynamic CT scan evaluating hepatic perfusion after liver transplantation. It is including three parts as following: l.To analyze the influence of different scan parameters on CTA and to explore the optimal scan parameters. 2. To evaluate the ability of CTA in detecting the hepatic artery complication and compare with DSA. 3. To compare hepatic perfusion values after orthotopic liver transplantation with those without hepatic disease.Part I The study of scan parameters on MSCT CTA Objective: To analyze the influence of different scan parameters of CTA and to explore the optimal scan parameters. Materials and Methods: 45 patients were performed on contrast multidetector CT scan using different parameters with high-injector, nonionizing contrast 1.3ml/kg>, 0.3ml/s and delay time 18s-20s. After scanning, postprocessing of 2D and 3D angiography were done on workstation GE Advantage Windows 4.0. We mainly detect the clearly artifact of vascular and tribute of hepatic artery to evaluate image quality of hepatic artery of CTA. Through analyzing the effect the major scanning parameters to image quality of CTA. We explore the optimal scanning parameters of good quality. Results: The optimal scanning parameters: 3.75 X4/11.25-. HQ mode^ overlapping reconstruction rate 70% and STD reconstruction method. We can acquire high quality of hepatic artery using above parameters. Conclusion: MSCT angiography can clearly show normal hepatic artery and its three-grade tributes.Part II Hepatic artery complication after liver transplantation:diagnosis with MSCT CTA and Compare with DSA Objective: The purpose of this study was to evaluate the value of MSCT in the diagnosis of hepatic artery complication in patients with liver transplants and compare that findings with DSA. Materials and Methods: 48 patients were perfomed CT using a multidector scanner, after IV injection of 1.3ml/kg of contrast material at 3ml/sec. The range from diaphragm to L3 verterbral levels. Arterial phase image were acquired at 18-20sec (3.75mmX 4, table speed 11.25mm HQ mode). 2D and 3D angiography were performed on GE Advantage Windows station. Among the patients, 48 underwent conventional angiography within a week. We detect if hepatic artery is stenosis( compared with distal diameter of anatomosis part) the degree of stenosis and shape range of hepatic artery stenosis. At last,we compare the findings of CTA and DSA.Results:Among the 48 patients,results of MSCT CTA were abnomal in 28 patient, it showed the hepatic artery to be patent form its origin to the anatomosis and stenosis slightly in 11 patients, stenosis median in 8 patients, stenosis severity in 5 patients and showed occlusion of the entire hepatic arteryin 4 patients. DSA firmed the diagnosis of hepatic artery complication in 28 patients, but DSA only showed occlusion of the entire hepation artery in 3 patients, slight> median^ severity stenosis in 12> 7 and 6 patients. In CTA, one is median stenosis, one is completely occlusion, but in DSA, They manifest slight and serve stenosis. Apart from that, the other results are consistent. Conclusion: MSCT angiography has safe noninvasive and accurate advantage for evaluating of hepatic artery stenosis after liver transplantation. It is the first choice of following hepatic artery after transplantation.Part III The study of hepatic perfusion after transplantation on MSCT Objective: To compare hepatic perfusion values after orthotopic liver transplantation with those without hepatic diseases. Materials and methods:30 patient during perioperation who have no complications and 20 normal volunteers were performed dynamic single-slice CT...
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