| Objective To evaluate the radioprotective effect of low dose mitomycin C on mouse intestinal epithelium. Method The technique of small intestinal crypt of mice was used to calculate the total cell survival per circumference of jejunum, then the relationship between total cell survival and radiation dose was established, and dose-survival curves were fitted, meanwhile, radioprotective factor (RPF) was calculated. Results Linear regression equations were that: Control group y1 = 10.7783-0.60335x1, test group y2=9.9732-0.4902x2. The differenc between the regression coefficients of the two groups was significant (P<0.05); RPF was 1.23. At the same radiation dose point, many lymphocytes were found in the mucosa of test group, however a few lymphocytes were found in that of control group. Conclusions low dose mytomycin C could decrease the radiation damage of mouse intestinal epithelium and had some degree of radioprotective effect. The mechanism of radioprotective effect of low dose mitomycin C might be due to its induction of adaptive response in mice and reduction of radiation damage to mice immume function.Postgraduate: Huang Bing-jian (Oncology) Directed by Zhou Ren-xiang...
|
PDF Full Text Request