The Value Of Bone Scintigraphy On The Extent Of Tumor Involvement In Primary Bone Neoplasms

[Objective] To study the value of bone scintigraphy on the extent of tumor involvement in primary bone neoplasms,compared with radiography. [Methods] (1) Planar scintigraphy was performed on rectangularstandard models of various size filled with pertechnetate to guarantee the optimal displaying condition of equippment for the measurement of boneneoplasms. (2) RBI was utilized on 30 rabbits with artificial lateral or bilateral tibial injuries imitating the behavior of bone neoplasms, 3 hours after intravenous administration of 185MBq99mTc - MDP . (3) 44 consecutivepatients with primary bone neoplasms were recruited for the study. The extent of bony involvement was obtained by RBI and radiography three days before surgery and was compared with pathological findings. [ Results ](D With a matrix of 512 x 512, the length of rectangular plastic models with the size of 3, 4, 5, 6(cm) was measured as 3.06±0.09, 4.01±0.19,4.99±0.10 , 5.99±0.10(cm) in terms of a specialized display condition (nonlinear Clipping transfer of 30% lower threshold)with a significance of . 05. (2) The actual bone injury of 1.85cm was estimated as2.90+0.28cm by RBI with a high significance of p<0.001. (3) Resection specimens of 44 bone neoplasms were pathologically analysed to identify type and size of each tumor and were compared with radiograpr^ RBI,respectively. The length of the tumor defined by RBL radiography andpathology was 5.59+.l.8K 3.74+1^ 4.64+1.86(cm), respectively,with a significance of p<0.05. There made differences between RBI and radiography, RBI and pathology(p<0. 05), respectively, with no difference betweenradiography and pathology(p>0. 05). The negative results of tumor cellswere pathologically confirmed in 33/34 specimens of malignant bone neoplasms displayed by RBI with in 18/34 specimens revealed byradiography, respectively. [Conclusion] Use of radiography evaluation alone could result in underestimation of the extent of a primary bone tumor, with risk of incomplete resection. RBI tends to offer specific guidelines in determining the appropriate extent of bone resection while entirely dealing the tumor cells and preserving functions whenever possible.