The Effect Of PCI On The Markers Of Sudden Death Of Coronary Artery Disease-QT Dispersion,Heart Rate Variability And Ventricular Late Potential

Objective: In order to elucidate the effect of PCI (percutaneous coronary intervention) on the markers of sudden death in patients with coronary artery disease and to estimate the prognosis of PCI in patients with coronary artery disease. The QTd (QT dispersion) HRV (heart rate variability) and VLP ( ventricular late potential) were assayed three days before PCI three days after PCI and one month after PCI, the effect of PCI on the three markers in patients with angina pectoris and myocardial infarction was analyzed too.Method: Sixty patients were selected consecutively from January 2001 to January 2002, whose diagnoses were defined by coronary arteriography and they were suitable to PCI. Among them 39 patients belong to the group of angina pectoris and 21 patients belong to the group of myocardial infarction. QTd HRV and VLP were assayed three days before PCI three days and one month after PCI. The valuesof QTd were obtained with 12-lead ECG and were analyzed by GE-Marquette QT Guard analysis system. The values of transient HRV and VLP were obtained from HRV analysis system and the electrocardial Station. The relation between them was tested with SPSS 10.0 software.Results: The values of QTd three days before PCI three days after PCI and one month after PCI were 39.46+ 14.85ms, 27.90+11.42ms and 26.85+9.66ms, respectively in patients with coronary artery disease. There were significant difference between those values before and after PCI (P<0.001) , but there were no significant difference between those values three days after PCI and one month after PCI(P>0.05). As for the values of QTd in patients with angina pectoris or myocardial infarction respectively, the effect of PCI on QTd of three days before PCI three days after PCI and one month after PCI was alike to the effect in patients with coronary artery disease. As for transient HRV and VLP, there were no significant difference among those values three days before PCI three days after PCI and one month after PCI (P>0.05) . As for the values of HRV and VLP in patients with angina pectoris or myocardial infarction respectively, the effect of PCI on HRV and VLP of three days before PCI three days after PCI and one month after PCI was alike to the effect in patients with coronary artery disease. The values of QTd between angina pectoris patients andmyocardial infarction patients had significant difference not only before PCI but also after PCI (P<0.05) ; but for HRV and VLP, the angina pectoris patients and myocardial infarction patients had no significant difference (P>0.05) . Conclusion: Successful PCI can supply enough blood to myocardium, and therefore shorten QTd. However, PCI has no effect on Heart rate variability and ventricular late potential. QTd can be served as a marker of prognosis in patients with coronary artery diseases.