Protective Effect Of Fructose-1, 6-Diphosphate In Open Heart Operation

Objective: To investigate the protective effects of exogenous fructose-1,6-diphosphate (FDP) in cardioplefic solution during cardiac surgery.Methods: Forty congenital heart disease patients were divided randomly into two groups each 20 patients, group I (control group) and group II (treated group), In the treated group, FDP was given to patients in cardioplegic solution (5mmol/L) . In the control group, replace FDP by 0.9%NaCl with the same volume. Blood samples, which were collected in both groups respectively before operation and 4 8 12 24 hours after aorta clamp opened, were used to test the serum levels of CPK, cTnT, at the meantime report total cross-clamp time and bypass time. Biopsy samples of the right atrium were taken at the beginning of the cardiopulmonary bypass and shortly after the end of aortic cross-clamped. The ultrastructural changes were analyzed.Results: 4 8 12 24 hours after aorta clamp opened, CPK and cTnT levels were lower in the treated group than that in the control group. 10 minutes after aorta opening, the changes of myocardial ultrastructure were more severe in the control group than that in the treated group.Conclusion: Exogenous FDP added into cardioplegic solution has a better myocardial protective effect.