| Objective and background: Cardiac arrhythmias are frequent problem in clinical practice. All arrhythmias result from disturbance in impulse formation, disturbance in impulse conduction, or both of all. Arrhythmias may be require treatment because too rapid, too slow, or anomalorhythm, such as tachycardia, bradycardia, premature beats, auricular flutter, ventricular flutter, ventricular fibrillation, auriculo-ventricular block and etc. As it is well known to all, potassium is very important to human body. Stabilizing of potassium is very important to maintain the function of cell. More importantly, hypopotassaemia is very harm to heart. The acute myocardial ischemia injury and administrating overdose digitalis may lead to potassium iron losing and some serious or even lethal disturbances, eg, early premature ventricular depolarization canprecipitate ventricular fibrillation. It has been shown that fructose-1,6-diphosphate(FDP) improves ischemic myocardial functoin and protects against ischemia reperfusion injury by restoring and enhancing energy metabolic processes .As reported previously ,potassium deficiency has ledto cytomembrane's depolarization and cardiac arrhythmias as well as myocardial ischemia injury and administration overdose digitalis, whereas it is prevented and attenuated by improving potassium concentration in myocardial cell. Working on the premise, it is sepeculated that potassium fructose diphosphate (FDPK) which is substituted potassium iron for sodium in fructose-1,6-diphosphate may take a synergetic effect to protect cardiac arrhythmias ,thereby it can make more markedly effect to protect cardiac arrhythmias .Meathod: In current study, the rats of myocardial ischemia reperfusion arrhythmias induced by ligation of coronary, ouabain-induced arrhythmias in the guinea pigs and hypokalemia in rabbit were used as models to investigate the protective effects of potassium fructose diphosphate on cardiac arrhythmias and their mechanisms.Result: (1) Potassium fructose diphosphate decreased the score of cardiac arrhythmias in myocardial ischemia reperfusion in rats. The effect of FDPK was mostly superior to fructose-1,6-diphosphate and Potassium Chloride. These results indicate that FDPK has good effect inantiarrhythmias. (2) Potassium fructose diphosphate increased +dP/dtmax, dP/dtmax in the rats suffered from acute myocardial ischemia reperfusion injury ,decreased LVEDP . The effect of FDPK was mostly superior to fructose-1,6-diphosphate and Potassium Chloride .These results indicate that FDPK have protective effect on myocardial ischemia reperfusion injury.(3)Potassium fructose diphosphate lowered creatine phosphokinase (CPK) and lactic dehydrogenase(LDH) activity in serum ,decreased CPK and LDH in myocardium .The action of FDPK was markedly superior to fructose-1,6-diphosphate and Potassium Chloride .These results indicate that FDPK have better protective effect than other drugs as above on myocardial ischemia reperfusion injury. (4) Potassium fructose diphosphate improved the activity of Na+,K+- ATPase , Ca2+- ATPase , Mg2+- ATPase, surperoxide dismutase (SOD) and reduced malondiadehyde (MDA) contents in myocardium .These results indicate that the mechanism of the protective effect of FDPK on myocardial ischemia reperfusion injury are related to improve ATPase activity as well as oxygen radicals. (5) Potassium fructose diphosphate can significantly increase Ouabain threshold dosage in ouabain-induced arrhythmias. The doses of ouabain produce ventricular extrasystole (VE), ventricular tachycardia (VT), ventricular fibrillation (VF), cardiac arrest (CA) were significantly increased .The effects of FDPK on ouabain-induced arrhythmias weregreater than those of fructose-1,6-diphosphate and Potassium Chloride. These results indicate that FDPK has good antiarrhythmic effects. (6) Potassium fructose diphosphate can greatly increase potassium concentration in Lymphocytic cell in circle blood. The effect of FDPK was mostly superior to fructose-1,6-diphosphate and Potassiu...
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