The Study Of Expression Of Bcl-2,Bax,Fas And Fas-L On Psoriasis Vulgaris

Objective: To study the expression and significance of Bcl-2, Bax, Fas and Fas-L on psoriasis vulgaris.Methods: Forty cases of psoriasis were examined with immunohistochemistry technic (LSAB) in psoriasis vulgaris of skin. Results: 1. There were significant overexpressions of Bax protein in all layers of epidermis, inflammatory cells and vascular endothelum in dermis(P<0.01) .2. No Bcl-2 protein expression was found in keratinocytes ; and the expression of Bcl-2 protein was like normal epidermis(P>0.05) , restricted only in melanocytes of the basal layer.3.Both Fas and Fas-L protein were expressed on the keratinocytes with basically the same distribution in psoriasis vulgarisl,the expression were statistically significant between psoriasis vulgarisl and normal skin(P<0.01) . There were obvious apoptosis of keratinocytes but reducedinfiltration of inflammatory cells.Conclusions:1.The down-regulated ratio of Bcl-2 to Bax contributes to the overproliferation of keratinocytes, intensive infiltration of inflammatory cells and hyperplasia of new vessels.2. No Bcl-2 protein expression was found in keratinocytes . So it is less important to the initiation of psoriasis vulgaris.3. The increase of apoptotic keratinocytes is possibly a kind of internal homeostatic mechanism against the hyperplasia of epidermal cells, and might relate to abnormal expression of apoptosis-associated proteins Bax, Fas and Fas-L, The Fas system might also take part in the abnormal local immunoreaction in psoriasis vulgaris.