The Expression And Relevant Clinical Significance Vascular Endothelial Growth Factor And Cyclooxygenase-2 In Non-small Cell Lung Cancer

Objective:By detecting the expression of Vascular endothelial growth factor(VEGF) and cyclooxygenase-2(COX-2) in the tissue of non-small cell lung cancer(NSCLC).paracancerous and normal lung tissues.we studied the effects of VEGF and COX-2 and the correlation between VEGF and COX-2 on the development of NSCLC.Methods: The expression of VEGF and COX-2 were detected in 60 cases of NSCLC, the same cases of paracancer tissues of NSCLC and 20 cases of normal lung tissues by imnuinohistochemical method.The experimental data was analysed with Chi squane test.Results: (1 )The rate of positive expression of VEGF and COX-2 were higher in the tissues of NSCLC than those in paracancerous tissues of NSCLC and in normal lung tissues .It was significantly difference(P<0.001).(2) The degree of expression of VEGF in NSCLC was relative to clinical stages(P<0.01),the size of tumor(P<0.05).metastatic lymponode (PO.Ol).but was not relative to the histologic classes and pathological types.The later clinical stage,the bigger tumor and the more metastatic lymponode .the higher rate was the postive expression of VEGF. (3) The expression of COX-2 in NSCLC was associated with clinical stage.tumor size,pathological type.histologic class or metastatic lymponode (P<0.01, P<0.05, PO.001. PO.05. P<0.01).The later clinical stage, the bigger tumor and the more metastatic lymponode the higher rate was the positive expression of VEGF. The rate of expression of COX-2 in adenocarcinoma was significantly higher than that in squamous carcinoma. The rate of expression of COX-2 in the well differentiated NSCLC was significantly higher than that in the poorly differentiated NSCLC.(4)The level of VEGF was closely related to the level of COX-2 in the carcinoma of NSCLC.Conclusion: These experimental results were suggested that VEGF and COX-2play an important roles in oncogenesis and progression of NSCLC.The higher positive expression of VF.GF and COX-2 were indication for the tumor growing quickly and the desease stage being later.and lymponode having metastasis.The overexpression of COX-2 was always detected in adenocarcinoma and well differentiated carcinoma in NSCLC. The expression of VEGF was closely related to the expression of COX-2.VEGF had took part in the development.invasion of carcinoma and lymponode metastasis togather with COX-2 in NSCLC. Detection the level of VEGF and COX-2 expression might be useful to judge the stage of desease and lymponode metastasis of NSCLC.and to predict the prognosis of patients with NSCLC.Also, this result was provided a fundamental theory for selecting chemical agents of inhibiting VEGF and COX-2 from action in the prevention and treatment of NSCLC.