Anti-Cancer Effect Of Ginsenoside Rg3 Alone Or Combined With Cytotoxic Agent On The Xenotransplanted Human Breast Infiltrating Duct Carcinoma In Nude Mice And Inhibition Of Angiogenesis.

Objective To Study the antitumor effect of Ginsenoside Rg3 (Rg3) alone or combined with cytotoxic agent on xenotransplanted human breast infiltrating duct carcinoma in nude mice and inhibition of angiogenesis.Methods A total of 16 female nude mice were randomly divided into 4 groups to receive cyclophosphamid (16mg/kg, qd) and Rg3(10mg/kg;qd), Rg3(10mg/kg, qd) alone, cyclophosphamid(16mg/kg, qd) alone and 0.5% sodium carboxymethyl cellulose (0.5ml, qd)respectively to each group for 55 days. Breast cancer mass were weighted and collected for light microscopic observation. The intra-tumoral microvessel density (MVD) and the expression of vascular endothelial growth factors (VEGF) were examined by immunohistochemical staining.Results: The tumor weights of treated group were significantly lower than that of control group. The tumor weight of the Rg3 combined with CTXgroup was lower than that of Rg3 group. The MVD value and VEGF expression of Rg3 group were significantly lower than those of CTX group and control group. The MVD was significantly reduced in the Rg3 combined with CTX group than others.Conclusions The application of Rg3 and Rg3 combined with CTX could inhibit the growth of xenotransplanted human breast infiltrating duct carcinoma, and reduce the intra tumorous MVD,and expression of VEGF as well.