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Experimental Study On Comparison Of Analgesic Effect On Scorpion Dust And Its Extract By The Technics Of Water Or Ethanol

Posted on:2003-05-09Degree:MasterType:Thesis
Country:ChinaCandidate:Y H TanFull Text:PDF
GTID:2144360065461078Subject:Pharmacy
Abstract/Summary:PDF Full Text Request
Scorpion was extremely mostly handled by the way of powder in the mud-Prescription preparation, which was exiting several malpractices. And when Scorpion decocted by high temperature, it was no reported whether its utility Components were destroyed and whether this manner of medication was reasonable. Extract technics of Scorpion was initially screened by analgesia test with Mouse bodies twisted with Acetic acid, the way of super-mini powder was excluded and the way of regurgitating in thin ethanol was initially found, in the advanced test of extract technics, taking the content of protein in Scorpion as evaluation index, mensurating it by the ultraviolet spectrophotography, studied technics of Scorpion extracted by soaking in cool water, decocting in water and Regurgitating in ethanol, all of which were screened by the orthogonal design. Under the condition of the same dose, the content of protein in Scorpion was the highest in the best technical of extract by Regurgitating in thin ethanol, that was: Scorpions were shattered into the powders of 20 meshs. after cryodrying and extracted by 50 % ethanol with four times of dosage of material drug regurgitated 30 minuter every time, three times again. According to the best technic respectively in the three-extract Methods, Preparations of Scorpion as drugs were produced, Analgesia Test was done again and the trial in model of migraine of mouse and rats were also done. All of study results showed although it was no significant in index of drug effect comparing the animal in the team of Extract-extract with the other extract teams, Index of drug effect in numeric valuewas better than or equivalent to the other extract teams. From the cost of Preparation, the cost of thin ethanol-extract could not higher than water-extract too much. From above,a conclusion was drawn that technics of Scorpion extracted by Regurgitating in 50 % ethanol is cardinally reasonable.
Keywords/Search Tags:Scorpion/protein of Scorpion, technics of extracting, orthogonal design, migraine, analgesic effect
PDF Full Text Request
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