The Changes And Effects Of ANP,ET,CGRP,and NPY In Plasma On The Patients With Qi-Defeciency And Blood-stasis Syndrome

OBJECTIVE:To study the changes and effects of ANP,ET,CGRP and NPY in plasma on the patients with Qi-deffeciency and Blood-stasis syndrome(QDBS).METHODS: The levels of ANP,ET,CGRP and NPY in plasma were measured by radioimmunnossary(RIA) in 40 patients with QDBS and 15 healthy elders and 20 youngers.RESULTS: 1)The levels of ANP in plasma in the patients with QDBS were significantly lower than in the healthy elder and healthy younger(p<0.05). There was no significantly change between the healthy elders and healthy youngers. 2) The levels of ET in plasma in the patients with QDBS were significantly higher than in the healthy elder and healthy younger(p<0.05). There was no significantly change between the healthy elder and healthy younger. 3)The levels of CGRP in plasma in the patients with QDBS were significantly lower than in the healthy elder and healthy younger(p<0.05). There was no significantly change between the healthy elder and healthy younger. 4) The levels of NPY in plasma in the patients with QDBS were significantly higher than in the healthy elder and healthy younger(p<0.05). There was no significantly change between the healthy elder and healthy younger.5) There is no difference between the two QDBS groups. CONCLUSION: 1)There are some vascular active substances changes in QDBS patients. The plasma levels of ANP and CGRP increase in QDBS patients. The plasma levels of ET and NPY decrease in QDBS patients.2) This test does not indicate that there are different changes of ANP,ET,CGRP,NPY in plasma in different diseases.