The Clinical Investigation Of C-reactive Protein In Patients With Essential Hypertension And Patients With Coronary Heart Disease

Objective: To observe the change of serum C-reactive protein (CRP) in patients with essential hypertension (HBP) and patients with coronary heart disease (CHD) ,and to analyze the relationship between C-reactive protein and some correlative clinical markers. To study the role of inflammation in hypertension and coronary heart disease.Methods: CRP was measured in 143 patients with essential hypertension -. 68 patients with coronary heart disease and 60 normal persons , at the same time , fasting blood glucose (FBG ), total cholesterol (TC), triglyceride ( TG ) , high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), leukocyte (WBC), body mass index(BMI) were also measured. Blood samples were taken in the morning and all investigation objects did not have breakfast. CRP was measured by immunoturbidimetric assay.Results: (1) Serum levels of CRP were significantly higher in patients with hypertension and patients with coronary heart disease (p<0.01); no difference between patients with hypertension and coronary heart disease (p>0.05);(2) Among patients with hypertension, serum levels of CRP increased gradually following the step-up of blood pressure, and the difference between hypertension grade 1 and grade 2 was significant. (p<0.05) ;(3) In HBP group,the contents of CRP has positive correlation with numeration of leukocyte ( p<0.05); (4) serum levels of CRP in AMI group and UAP group were significantly higher than in SAP group (p<0.05), but no difference between the former two groups (p>0.05); (5) CRP has positive correlation with age,TG and FBG, negative correlation with HDL-C(p<0.05).Conclusion: (1) CRP is an inflammation marker and serum levels of CRP in patients with hypertension and in patients with coronary heart disease are significantly higher than those in normal persons, which suggests tissue damage and inflammation reaction in HBP patients and CHD patients;(2) the contents of CRP have the tendency of increasing with the step-up of blood pressure and serum levels of CRP in AMI group and UAP group are also significantly higher than in SAP group (p<0.05), which suggests the levels of CRP react the degree of disease correspondingly. (3) Perhaps hyperglycemia and hypertriglyceridemia participate inflammation reaction, so controlling hyperglycemia and hypertriglyceridemia may be relieve inflammation reaction and improve the condition of patients.