Study On Influence Factors Of PDT Treat Malignant Tumor

Photodynamic Therapy ( PDT) is a kind of effective treatment means to the malignant tumor. Experiment find laser shine dosage enough accurate in size among PDT treatment and document in the past, it is less likely to involve the quantitative relation between various kinds of influence factors, thus influenced the result of treatment of PDT , it is an important problem influencing PDT to popularize and apply too so far. This subject set about from the aspect, probe taking animal' s tumor as model mere power the quantitative research of relation in treating tentatively. Hope through study and can find necessary light shine dosage and tumor photosensitive density and organize oxygen quantitative relation of content of medicine in organizing when treating in PDT, Thus improve curative effect, popularize and apply the reference of offering for PDT. First of all, this text summarize domestic and international research state of PDT, exhaustive exposition PDT treat the principle and mechanism of the malignant tumor comparatively, treat to mere power photosensitive medicine, light source and oxygen, member these three key elements of course describe, he semiconductor laser of 630nm is a light source, which is suitable for the HpD photosensitive medicine.Secondly, confirm experiment spend tumor model little sarcoma, S180 of mouse, Analyze and think Chinese market sanction clinical blood hematoporphyrin derivative (HpD) that use one more ideal PDT photosensitive medicine only at present, ration determine tumor body and HpD density distribute the law changed with time in organizing normally. Through study and verify PDT the one hour tumor the density of HpD is highest of organizing behind note medicine when treating further, And HpD content while organizing normally at this moment is least.In addition , to determine this text oxygen content method carry on preliminary research in organizing, take the lead in and propose and reflect indirectly with the partial pressure of oxygen that organizes the view containing oxygen quantity, through determine oxygen partial pressure understand and organize oxygen change law of content indirectly. Find short time face guard suck high-density method of oxygen raise the oxygen content while organizing.Finally, thesis on the basis of testing in advance, propose and establish laser shine dosage, tumor HpD density, oxygen content and PDT result of treatment amount relation method of result in organizing, Adopted and returned to the analytic approach and has been got off a relational expression .By this popularize for PDT clinical practice offer reference, give it to a clinician with quantitative guide at the time of treating in the future, in order to receive better result of treatment.On the basis of job of this text, have been summarized and improves imagining to the subject. Propose and video equipment lead and down PDT get involved the developing direction treated to the tumor.