Effect Of Lidocaine In Systemic Inflammatory Response Syndrome Caused By Cardiopulmonary Bypass

Objective To investigate the effect of lidocaine in systemic inflammatory response syndrome(SIRS) caused by cardiopulmonary bypass. Methods: 30 rheumatic heart disease patients were randomly assigned tothree groups (n=10 for each group ).A(control group).B(aprotinin group,dosage 100,000KIU/kg,1/2 of dosage dripped introvenousely before CPB, 1/2 of dosage added in CPB machine).C(lidocaine group.a single dose of lidocaine 2mg/kg was administered before CPB and thereafter infused at a rate of 2mg/kg/h during CPB period).6ml radial artery blood was taken in each of the five time points.T1(before CPB) ,T2(30 min after aortic clamping ),T,(termination of CPB),T4(2 hours after CPB),T,(24 hours after CPB).Blood samples were centrifuged(l,500r/min) promptly.Samples were stored below -72 C The plasma levels of TNF- a ,IL-6andIL-8 were analysed by ELISA within 3 months.Resu I ts:The concentrations ofcytokines(TNF- a ,IL-6,IL-8) increased from the beginning of CPB,then reached peak levels after 2 hours of CPB,and came back to normal after 24 hours of CPB.The plasma contents of TNF- a ,IL-6andIL-8 reduced significantly in aprotinin and lidocaine administration groups compared with control group.there was nosignificant change between group B and C.Conclusions:CPB induces the releaseof cytokines thereafter causes systemic inflammatory reponse syndrome.Lidocaine can decrease the levels of proinflammatory cytokines in plasma and therefore attenuate the systemic inflammatory response caused by CPB.