Font Size: a A A

Clinical Presentation And Statistical Analysis Of Angioarchitectural Indices Of Cerebral Arteriovenous Malformations

Posted on:2003-12-08Degree:MasterType:Thesis
Country:ChinaCandidate:L S HuiFull Text:PDF
GTID:2144360092965090Subject:Surgery
Abstract/Summary:PDF Full Text Request
In the first part,we collected and analysised 204 cases of AVMs simply. We described distributations of age of admission,age of episode and duration of housing and analysised presentations of AVMs in various locations using 2x2 table x2 test. Age of episode was defined as the time when principal associated presentations occurred. The results demonstrated that age of admission,age of episode are both of normal distribution while days of housing are notThe average age of episode was 27.1,95% interval was (24.9,29.2) and the average age of admission was 31.4,95% interval was (29.3,33.5).The difference of the means was 4.3 years. The median of days of housing was 19. 54% of the AVMs were diagnosed as the consequence of hemorrhage 1% of epilepsy,14% of headache or dizziness and 11% of hemiplegia,anepia,sight damage or mental disorder. The result of x2 test demonstrated that the rate of hemorrhage at basal ganglions was higher (P<0.05) and the value of OR was 4.5. AVMs in post-fossa was not a facter that can cause hemorrhage(P>0.05). The risk of hemorrhage or epilepsy was not significantly higher in both left or right hemisphere. Complications occurred in 23.6% cases after emblism,36.7% after operation and 25% after emblism and operation.The second part emphasized to evaluate the clinical and angioarchitectural indices of cerebral arteriovenous malformations(AVMs) to identify the main factors that were correlated with the presentation of hemorrhage. Then an equation that can predict the probability of hemorrhage can be created to help estimate and cure cerebral arteriovenous malformations.40 cases with presentation of hemorrhage and 40 non-hemarrhagic cases were reviewed and 24 indices and 30 levels were evaluated. Univariate and multivariate analysis were performed with the Logistic regressionmodel. When P=0.01,age,the longest diameter of AVMs,volume of AVMs,number of feeding arteries,diameter of the main feeding artery,classification in our nation and history were negatively correlated with hemorrhage while direction of drainaging veins were positively correlated with hemorrhage;When P=0.05,A/V time,the mean artery pressure were negatively correlated with hemorrhage while location,number of main drainaging veins and diameter of the main drainging vein were positively correlated with hemorrhage. The longest diameter of AVMs,direction of drainaging veins and history were introducted in the equation eventually. The sensitivity and specificity were both 80%.The longest diameter of AVM,direction of main drainaging veins and history was the most important indices in predicting hemorrhage.In this part we also studied the correlation of hemorrhage of AVMs and its hematological facters. The group of hemorrhage was defined as having bleeding history recently or having been diagnosed clearly. The non-hemorrhagic group all had no history of hemorrhage and were conformed with screenage examines. The results demonstrated that PT was higher in AVMs (PO.01),but KPTT and TT were both had no significant difference in AVMs and in normal group(P>0.05). Hemorrhage group and non-hemorrhage group had no difference(P>0.05). It demonstrated that hematologic dysfunctions were not bleeding factors of AVMs.In the third part we analysised the clinical and angiographic indices to identify the main factors that were associated with epilepsy in cerebral arteriovenous malformation patients. Then to creat an equation that can predict the probability of elepsy to help estimate and cure cerebral arteriovenous malformations. 23 indices and 29 levels of 61 cases were observed and analysed using the Logistic regression model. Location,number and origion of main feeding arteries,diameter and direction of main drainaging veins and size of cerebral arteriovenous malformations were associated with elepsy;Sex,oringion of main feeding arteries,ratio of number of main feeding arteries to main drainaging veins and size were introducted in the equation eventually. Insufficient drainage of local functional cortex may be the cause of elepsy.We als...
Keywords/Search Tags:cerebral arteriovenous malformations, clinical presentations, angioarchitecture, statistics
PDF Full Text Request
Related items