| Objective: To enhance the understanding of the clinical characteristics of vascular dementia(VD) for improving its diagnostic quality. Methods: The subjects included thirty VD patients, thirty cerebral infarction patients without obvious congnitive deficits and thirty normal agings. The cognitive fuctions of the subjects were assessed by Mini-Mental State Examination(MMSE), Brief Screening Scale for Dementia(BSSD) and CLOX (clock drawing task). The event-related potential P300 of the subjects evoked by auditory stimulation were recorded and analysed. The focal cerebral lesions and the cerebral atrophy were analysed by CT scan .Results: (1)VD patients had obvious cognitive disorder in attention, short-term memory, calculation, verbal comprehension, verbalization, read comprehension, time orientation and visuospatial cognition. (2)The P300 peak latencies (PL) significantly prolonged in VD patients. (3)The patients with multiple infarction were more frequently seen in VD patients than in cerebral infarction patients without obvious congnitive deficits. (4)Cerebral atrophy especially the atrophy of frontal lobe was common in VD patients. (5)The resistence index(RI) of most cerebral vessels in VD patients increased. (6)There were more sufferers with a history of stroke and hypertension in VD patients than in cerebral infarction patients without abvious cognitive disorder. Conclusions: (1)Disorder in the memory, attention and the functions related to language and visuospatial cognition are prominent in the cognitive deficits of VD patients. (2)The cognitive disorders are the common complication in cerebral infaction patients. (3) P300 PL is an objective index for assessing the cognitive function of VD patients and cerebral infarction patientswithout abvious cognitive disorder . (4)The atrophy of the frontal lobe and the white matter underneath is the risk factor of VD. (5)Hypertension , cerebral arteriosclerosis and repeated apoplexy are all the risk factors of VD. |
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