Clinical Studies On The Kidney Asthenia With Blood Stasis Syndrome Of Vascular Dementia

Objectives: To investigate the changes of ET, NO, ET/NO, E2, T and relationship to the kidney asthenia with blood stasis syndrome (KABSS). To observe the effect of combination of kidney reinforcing and blood act stasis removing, which provides the indexes for clinical treatment of VD.Materials and Methods: According to the DSM-IV-R diagnosis criteria and TCM differentiation standards, 70 patients (31 female and 39 male) of KABSS of VD were selected, average age of 70. 25?. 08 (60-80) and whose integral of blood stasis syndrome of TCM was 20 or more. 40 patients of them were treated with Chinese herbal medicine as Chinese herbal medicine group and the others with western medicine as western medicine group. At the same time, 30 healthy aged people were selected as a control ..(19 male and 11 female), average age 69. 23?. 46 (60-78). The plasma ET and serum E2, T level were determined by radio immunoassay. The plasma NO level was determined by nitrate raductase colorimetric and the plasma HCY by enzyme linked immunosorbent double antibody method.Results: 1. The plasma ET, HCY level and ET/No in KABSS of VD weresignificantly higher than those in the control (P<0.01). While NO in KABSS of VD was significantly lower than that in the control (P<0. 01). 2. Due to the different degree of KABSS patients were divided into three groups (mild, moderate and severe). The regular change of ET, ET/NO and HCY was: Mild syndrome groupmoderate syndrome group>severe syndrome group (P<0.01). 3. The plasma E2level in the female patients of KABSS of VD was significantly higher than that in the female control (P<0. 05), and the plasma T level was remarkable lower than that in the female control (P<0. 05). Nevertheless, the serum E2 level in the male patients of KABSS of VD was significantly higher than that in the control and the serum T level was remarkable lower than that in the male control (P<0. 05). The serum T level of mild syndrome group was higher than that of severe syndrome group. 4. The amount of integral blood stasis syndrome has a significant positive correlation with ET, ET/NO, HCY, and has a notable negative correlation with NO, but has no correlation with E2/T. 5. The combination of kidney reinforcing and blood act stasis removing can decrease the plasma ET, HCY, E2 (male) level and increase the plasma NO, E2 (female), T (male) level as well as improved the clinical symptoms and signs. So it is superior to the western medicine.Conclusion: The disturbance releasing of ET, NO, HCY, E2, T may be related to the occurrence and development of the KABSS of VD . These indexes can serve as a reference to judge the existence of KABSS. And the combination of kidney asthenia and blood act stasis removing can improve the clinical symptoms and signs. It was a basic treatment ofVD.