| Aim Our previous clinical studies have indicated Tablet of santong naotong can effctively faciliate the recovery of acute cerebral ischemic patients,to discover the mechanism of Tablet of santong naotong on the treatment of cerebral ischemic vascular diseases. We studied the morphosis,learning and memory recovery and oxid free radical of the rats'cerebral function. Methods The MCAO (middle cerebral artery occlusion) rat models were made by nylon thread embolus. The rats were divided into six groups at random before given Tablet of santong naotong.We observed the variety of rats'nerve signs and common situa tion,detected the change of rats' learning and memory function by Morris water mate and melanotrophy experment,detected nitric oxide(NO),endothelin (ET),super-oxide dismutase (SOD),MDA,glutathione peroxidase (GSH-PX) of blood,observed the change of rats cerebral cellular morphosis by HE stain.The expression of introduced nitric oxide synthase(iNOS) were observed by immunohistochemistry.Result The results showed Tablet of santong naotong could accelerate the disappearance of pathological nerve sign,learning and memory recovery rats' acute cerebral ischemia.Tablet of santong naotong could decline the amount of NO ,MDA and SOD, but had not obvious effect on the level of ET and GSH-PX in the blood. Tablet of santong naotong had obvious influence on the expression iNOS in the endothelial cell,Tablet of santong naotong candecrease the mortality of neuron in the CA1 region of the hippocampus in the acute stage after MCAO,also could decrease the express of iNOS in neuron of the ischemia.Conclusion Tablet of santong naotong can accelerate the disappearance of pathological nerve sign ,tearning and memory recovery and decrease the mortality of neuron and the production of oxid free radical of rats' acute cerebral ischemia,decrease the amount of NO and the express of iNOS in neuron of the ischemia.
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