| More studies have now confirmed that dyslipidemias are major risk factors for atherosclerosis and coronary artery disease. Perturbation in lipid metabolism is common during aging, such as primary hypertriglyceridaemia, primary hypercholesterolaemia and combined hyperlipidaemia. Peroxisome proliferator activated receptors (PPARs) are a family of three transcriptional factors, PPAR , / and , which can be activated by fatty acids and mediate the balance of lipid metabolism. PPAR subtype is close related to lipid metabolism?the effect of PPAR on metabolism of triglyceride-rich lipoprotein and fatty acid , and activation of PPAR a increasing catabolism of triglyceride and fatty acid at several levels.In the present study, we used two-group rats at different ages (4 weeks and 24 months) . Triglyceride(TG) and total cholesterol (TC) levels were compared between two groups. The mRNA and protein expression levels of PPAR in the liver were measured by reverse transcription polymerase chain reaction (RT-PCR) and western blotting, respectively. The results showed TG and TC were higher in the aged than in the young group(TG 1. 16?. 41 vs 0.71 0. 19, P<0. 01 TC 2. 31 0.65 vs 1.91 0.39, P<0. 05). The effect of aging on the PPAR a was examined. Significant negative correlation is observed between age and mRNA(r=-0. 52, P |
PDF Full Text Request