The Study Of The Plasma Soluble Inter-cellular Adhesion Molecule-1 And It's Correlation To The Activity Of Peripheral Blood Lymphocyte NF-κB P65 In Acute Coronary Syndrome

In the acute coronary syndrome there is an unexpected and sudden development of ischemia which has been attributed to plaque rupture and subsequent thrombosis, not to the stricture of coronaries .Indeed some foreign autopsy studies have failed to identified fissures associated with 10% to 40% of coronary thrombi in patients with fatal myocardial infarction. Conversely, plaque fissuring may be found in 10-25% of patients dying from non-cardiac causes. The potential role of inflammation in plaque rupture in acute coronary syndrome has become increasingly recognized. From a clinical perspective, early detection of these plaques may prevent the occurrence of serious coronary events. Unfortunately, current diagnostic techniques -i.e. angiography- do not allow the characterization of events taking place in the arterial wall. Therefore, these diagnostic tools cannot identify vulnerable plaques. Recent studies have suggested that markers of systemic inflammation may help in the detection of high risk patients. Soluble inter-cellular adhesion molecule-l is a potential marker of inflammation ,often being researched. Nuclear factor- κ B is a redox-sensitive transcription factor regulating a battery of inflammatory genes. sICAM-1 and NF-κ B have been implicated as important for initiation and progress of pathogenesis in acute coronary syndrome, but their correlation is unknown. Toinvestigate the difference of activity of NF- κ B p65 and it's correlation to the plasma soluble inter-cellular adhesion molecules in acute coronary syndrome and explore the potential perspective factor for the acute coronary syndrome(ACS). Enzyme-linked immunosorbent assay was used to measure the plasma soluble inter-cellular adhesion molecules and immunohistochemical method was used to measure activity of NF- κ B p65 in peripheral blood lymphocyte. The levels of activity of NF- K B p65 in peripheral blood lymphocyte and the plasma soluble inter-cellular adhesion molecule-1 were significantly higher in patients with ACS than in those of the controls(P<0.01) and in patients with stable angina pectoris (P<0.01).The level of the plasma soluble inter-cellular adhesion molecule-1 was positively correlated with activity of NF-κ B p65 in peripheral blood lymphocyte (r=0.378, P<0.05) . The elevated levels of the plasma soluble inter-cellular adhesion molecule-1 and activity of NF-κ B p65in peripheral blood lymphocyte in ACS suggested the possible relation to the pathogenesis of ACS, which may save as a potential marker of plaque unstability. The positive correlation between soluble inter-cellular adhesion molecule-1 and NF-κ B p65 may indicate the possible mechanism by which NF- K B facilitates the ACS via up-regulation the soluble inter-cellular adhesion molecule-1 expression.