The Study Of Prescription Screening And Pharmaceutics On Naoxinkang Capsule

Stroke is a kind of clinical common disease. And its onset often leaves behind much aftereffect in different degree. So it is one of the diseases that endanger the health of people age 45 or over. In recent years, researchers apply modern scientific technique to study Traditional Chinese medicine compound which can cure stroke, and they made great progress. But there are still some limits in preparation. The compound should be made of fewer ingredients in order to reduce the dosage and make the preparation suitable for the clinical use. At the same time, the pharmacokinetics value should not be depressed.The original clinical practical preparation has many ingredients, in which there are much complex elements. The thrombus wet weight and dry weight was used to evaluate the effect. Thrombosis experiment outside body was applied to sift the original preparation and confirm the new preparation. The new preparation consists of Radix Astragali, Panax quinquefolium, Panax pseudo-ginseng, Cornus officinalis, Hirudo, Lumbricus, Eupolyphaga Seu Steleophaga.Orthogonal-designed experiments were used to sift the best abstraction technics. With HPLC-ELSD method the content of Astragaloside IV was determined. The best abstraction technics is that using 8 times 70% alcohol extract 2 times which time is 2 hours. The determination result of Astragaloside IV in new capsule is 0.51mg g-1.