Synthesis 3-Substituted Indolin-2-ones: A Novel Class Of Receptor Tyrosine Kinase Inhibitors

The development of angiogenesis inhibitors was described in this paper , including its anticancer mechanism. The inhibitor of VEGF receptor tyrosine kinase was introduced in detail.3-Substituted indolin-2-ones was a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinase ( RTKs ) .Based on the analysis of structure-activity relationships ( SAR ) of 3-substituted indolin-2-ones , thirty-one target cimpoumds were designed and prepared . twenty-three of them were new compounds.The structure of the target compounds were confirmed by IR, ]HNMR, MS ( to YD2,YD33 ) .The pharmacological evaluation of these target compounds is in process.