The Development Of NaoDeSheng Soft Capsules

To meet the needs of Traditional Chinese Medicine Modernization and introduce Chinese Medicine to the worldwide, we need to not only change its unitary status of one form and develop more forms other than Pill of Chinese Medicine, but also conduct quantitative analysis of the major medicine components to control its qualities.The formula of Nao De Sheng (NDS) comes from Chinese Pharmacopoeia. The major effects of this medicine include reducing stasis and improving blood circulation, mediating main and collateral channels, and regaining consciousness. It is a remedy for cerebral arteriosclerosis, stroke and sequelae of cerebral hemorrhage. It has a longer use time and leads to more accurate effects.In this research, under the guidance of the traditional Chinese medicinal theory and practice, orthogonal method was designed to screen the extraction procedure of all drug components to get the best one. After purifying all the components by using macroporous resin, and results in new form of Traditional Chinese Medicine - Soft Capsules.Quantitative analysis was carried out on ginsenoside Rgi, ferulic acid,puerarinand safflor yellow by HPLC, spectrophotometer method andtitration method to ensure quality control of NDS soft capsules.The method was prove to be simple,precise and reproduciable.It is especially practicable for rapid analysis in production. Its stability was also investigated.Using anti-thrombus and protection effects of the cerebral ischemia as the drug efficacy standard, pharmacological experiments were done to compare the drug efficacy between NDS soft capsules and pills, providing the drug efficacy and quality control evaluation standards for NDS new drug form research in the future.