Study On The New Anti-Ulcer Complexes Of H₂-Receptor Antagonists And Zinc

This paper reviewed the pathogenesis of digestive ulcer and clinical application of anti-ulcer medicines. Based on the combine theory, a series of double anti-ulcer function complexes of Histamine H₂-Receptor Antagonists and Zinc were designed and synthesized.Through the complexation of H₂-Receptor Antagonists and salt of Zinc, nineteen binary or triple center complexes were synthesized in the paper. Of them .fourteen compound have not been reported hi literature. Their structures were identified by IR, UV, TG-DTA, X-ray and as well as titration and elementary analysis.As a result of the preliminary pharmacodynamic experiments, most of the complexes showed significant anti-ulcer and cytoprotective activity against stomach ulcer of mice respectively induced by absolute alcohol and aspirin. Among them , the ulcer exhibition activity of complex C-04,C-05,C-10,C-11 is obviously stronger than cimetidine , and the activity of complex R-01 , R-04, R-05, F-02 , F-03 is also much stronger than their contrast medicine.