A Clinic Analysis Of Gestational Trophoblastic Tumor In 122 Cases

Objective To investigate clinic treatment of gestational trophoblastic tumor (GTT).Methods 122 cases of GTT who were admitted in our hospital form Jan. 1990 to Dec. 2002 were analyzed restrospectively.Results 92 cases of the hydatidiform mole use suction curettage. This treatment is used from one time to five times for different patients. 21 of 92 patients are given prophylactic chemotherapy. The malignant rate of patients whose times of suction curettage exceed three is higher than those whose time is from one to two. In hydatidiform mole 62 of 92 patients develop subsequent malignancy. In malignant trophoblastic tumor, 53 patients were treated with chemotherapy, 33 patients were treated with chemotherapy and surgery. The response rate of the two methods are similar. 10 high-risk GTT patients were treated with EMA/CO regimen (Etoposide, Dactinomycin, Methotrexate, Vincristine, Cyclophospha-mide).Conclusions In hydatidiform mole, those patients with suction curettage for several times exceed the risk of malignancy. The hydatidiform mole at high risk can be use prophylactic chemotherapy in time. The first choice of treatment in malignant trophoblastic tumor is chemotherapy, some of patients were treated with surgery. EMA/CO regimen seem to be the first choice of high-risk malignant trophoblastic tumor.