The Level Of Testosterone In Acute Coronary Syndrome And Short-term Prognosis

Acute Coronary Syndrome(ACS) includes Unstable Angina Pectoris(UAP), Acute Myocardial Infarction(AMI) and coronary sudden death.lt is a common emergent and dangerous case.Testosterone has been found to be benifltial to coronary heart disease. Testosterone not only maintain the second sex character, but also has good effect on cardiovascular. In this article, we measured the level of the testosterone in patients with ACS in order to analyze the relationship between testosterone and ACS.Subjects and methods1. Inclusion: 31 patients admitted to the first hospital attached to China Medical University due to ACS, including UAP and ACS, were registered from March, 2002 to December, 2002.2. Exclusion: rheumatic heart disease (mitral stenosis and mitral incompetence, aortic stenosis and aortic incompetence); hypertrophic myocardiopathy.3. Statistical analysis: all data was summarized with meani standard devision. The difference between ACS group and control group was analyzed with t test. A p<0.05 is of statistical significance.Results1. The level of testosterone in ACS group was lower than that of in control group and was of statistical significance between the twe groups(p<0.05). The mean value was 46.84±7.17ug/L and 59.15 ± 5.68ug/L respectively. The level of TC, TG, HDL-C and LDL-C between them was of no statistical significance with t test.2. 31 patients were followed-up for 3 months.3 patients were lost. In the other 28 patients, 8 patients were accompatied with heart events.3. The level of testosterone was lower than 40ug/L in these patients and was higher than 40ug/L in those with no heart events.DiscussionThe rate of cardiovascular in men is much higher than that of in women. In addition to hypertension, diabetic mellitus and other risk factors of CHD, man sex is still a independent risk factor of cardiovascular disease. The level of testosterone is relative with age. It reaches peak at age of 20-24 and reduces gradually with the increasing of age. It is reported that the level of testosterone in patients with CHD is much lower than that of in normal men.The result of this article showed that the level of testosterone reduced in ACS group. The causes as followed: 1. Testosterone affects lipid metabolism. For example, it reduces LDL-C, TG and TC. 2. It has been found that testosterone can dilate coronary artery directly. 3. Testosterone can affect coagulation system. 4. Testosterone hasbenifitial effects on vascular endothelial function.The article of the relationship between testosterone and CHD is not the same at home and abroad. But most of the researchers admitted men with lower level of testosterone tend to have CHD. Patients in this study were followed up only for 3 months. It showed men with lower level testosterone had bad prognosis, compared with those more than 40ug/L.Testosterone has benifitial effects on men with CHD. To date, the multiple-centure clinical trial of androgen implentmention treatment is on-going. We believe that we can get benifitial results which will be used in clinical practice. It will improve qulity of life in patients with ACS who lack of androgen in old men.