Clinical Study On Correlation Of Testosterone And Risk Factors In Males With Acute Coronary Syndrome

Background:Study showed that significant differences in morbidity of acute coronary syndrome (ACS), one of critical coronary diseases, was found in different sexes. Despite other risk factors, Males was recently found to be a dependent one. More evidence is needed to demonstrated the testosterone is either susceptible or protective factor to ACS, as scant study on the other hand, the roles of testosterone in activation of inflammatory reactions and coagulative and fibrinolytic systems remains to be demonstrated in ACS. Our present study is try to evaluate the correlation of testosterone in the pathogenesis of ACS, its activation of inflammatory cytokines and coagulative factors. Aims: Try to evaluate; the correlation of testosterone on the pathogenesis of ACS, activation of inflammatory cytokines and coagulative factors, verify the roles of the testosterone in the pathogenesis of ACS in male patients. Methods: 60 male ACS patients randomly divided into two groups: acute myocardium infarction (AMI) (n=30) and unstable angina pectoris (UAP) (n=30), 60 male un-ACS patients were enrolled as control group. Serum total testosterone ( TT ), free testosterone ( FT ) , matrix metalloproteinase-9 (MMP-9), tissue-inhibitor of metalloproteinase-1 (TIMP-1), tissue Factor (TF), tissue factor pathway inhibitor (TFPI), soluble intercellular adhesion molecule-1 ( sICAM-1), c-reactive protein (CRP ) and white blood cell (WBC )...