Clinical Study Of Yiyuanbaoshen Decoction Combined With Fosinopril Treating Early Type 2 Diabetic Nephropathy With Deficiency Of Qi And Yin With Blood Stasis Syndrome

Objective: To discuss the clinical curative effect on early type 2 diabetic nephropathy (DN) with deficiency of Qi and Yin with blood stasis syndrome by using Yiyuanbaoshen decoction combined with fosinopril.Methods: 90 cases of inpatients with early type 2 diabetic nephropathy with deficiency of Qi and Yin with blood stasis syndrome from January 2002 to February 2003 were selected and divided into three groups randomly(treatment group, Chinese medicine contronl group and western medicine contronl group),and were treated with Yiyuanbaoshen decoction combined with fosinopril, Yiyuanbaoshen decoction and fosinopril respectively for 2 months in additon to gliquidone(60mg a day) as a basal treatment. The curative effect and Chinese medical syndromes were observed. Moreover,urinary-albumin-excretion-rate(UAER), urinary N-Acetyl-β-D-Aminoglycosidases(NAG), fasting plasma glucose(FPG), post-prandial 2-hour plasma glucose(2HPG), glucohemoglobin A₁C (GHbA₁C), blood lipid and the index level of blood rheology were measured and compared before and after treatment.Results: The total effective rate of Yiyuanbaoshen decoction combined with fosinopril treating early type 2 diabetic nephropathy with deficiency of Qi and Yin with blood stasis Syndrome was 89.3% while Chinese medical syndromes improvement rate was 96.4%, and the results showed it had a cooperative effect with gliquidone. Moreover, it decreased the levels of UAER, urinary NAG, 2HPG, GHbA₁C,and blood lipid, and improved the index level of blood rheology, and all of above were more significantly enhanced compared with Chinese medicine control group and western medicine control group(P <0.05). Conclusions: Yiyuanbaoshen decoction combined with fosinopril is effective in treating early type 2 diabetic nephropathy with deficiency of Qi and Yin with blood stasis syndrome.