The Curative Effect Research On Zhi Gan Qing Treating Acute And Chronic Fatty Liver

Objective: To investigate the effect of Zhi Gan Qing Chinese drugs on treating fatty liver rats with hyperlipemia and acute fatty liver mouses models and explore the mechanism of them. Method: Fatty liver rats with hyperlipemia model was induced by feeding the rats high fat diet, and acute fatty liver mouses model was produced by injecting Dexamethasone Sodium Phosphate injection in the animals' abdomen and feeding mouse high fat diet at one time. Then the models were prevented and treated with high dosage, medium dosage and low dosage of Zhi Gan Qing Chinese drugs respectively contrasting with Chinese traditional medicine Zhi Bi Tuo and Western medicine Simvastatin tablets. The index of blood sugar, blood serum grease, liver grease, liver pathology was observed and compared between each group. Results: (1) Zhi Gan Qing Chinese drugs lowered high blood sugar of fatty liver rats with hyperlipemia model, and heighened low blood sugar of acute fatty liver mouses model. Zhi Gan Qing Chinese drugs adjusted blood sugar balancely. (2) Zhi Gan Qing lowered index of liver of acute fatty liver mouses. (3) Zhi Gan Qing lowered the two models total cholesterin, triglyceride in blood, and heighened high density lipoprotein, lowered lipid in serum. (4) Zhi Gan Qing lowered the two models total cholesterin, triglyceride in liver, and prevented fatty liver. (5) Zhi Gan Qing improved pathologic changes in liver to a degree.