Relationship Between Surficial Or Interfacial Properties And Blood-compatibility Of Carbonaceous Biomaterials

Carbonaceous materials have been widely used as biomaterials for their steady chemical properties, favorable abrasive wear resistance and biocompatibility. Allowing for that implanted materials interact with blood mainly by their surface, it is of great importance to find out the relationship between surficial or interfacial properties and hemocompatibility of carbonaceous biomaterials. It will help to provide advice for selection of composition in materials design and control of technics in materials preparation.In this paper, a lot of surficial properties are measured and hemocompatibility evaluations of carbonaceous biomaterials are carried out, whereafter the relationship between them is analyzed using Grey System Theory. Among the surficial properties, the chief one is obtained by analyzing the mechanism that affect the haemocompatibility of carbonaceous materials.Diamond-like Carbon Film (DLC) was prepared by means of plasma immersion ion implant-ion beam enhanced deposition (PIII-IBED), and Diamond Film was prepared by Microwave Plasma Chemical Vapor Deposition (MPCVD). The surface roughness, H%, the ratio of sp2/sp3 and surface energy of each carbonaceous biomaterial was measured by atomic force microscopy (AFM), IRspectroscopy, Raman spectroscopy, and contact angle technology. The haemocompatibility of carbonaceous materials was evaluated by Kinetic clotting time, Platelet consumption and hemolysis.The Grey Interconnect Degree is employed to evaluate the relationship between surface properties and hemocompatibility.The results of experiment are listed below.(a) It is found in preparation process of diamond-like film that the ratio of sp3 increases as the film grows. As one can see, the value of ID/IG decreases as the hydrogen content rises, indicating the increasement of the ratio of sp3.(b) Deng' Grey Interconnect Degree is not feasible to analyze the relationship between surface properties and hemocompatibility of carboneaous biomaterials, while the improved grey interconnect degree introduced in this paper can achieve a favorable result.(c) Hydrogen content is the chief factor that affects the kinetic clotting time of the carboneaous biomaterials.(d) Surface roughness content is the chief factor that affects the platelet consumption of the carboneaous biomaterials.(e) Interfacial tension is the chief factor that affects the hemolysis ratio of the carboneaous biomaterials.(f) It is important to evaluate the capability of carboneous biomaterials to resist the transition of fiberinogen's electron. It may be another crucial surface property that affacts the biomaterials' hemocompatibility.(g) A carboneous biomaterial with favorable hemocompatibility may bear such surface properties as high polar fraction in surface tension, smooth surface, appropriate hydrogen content, sp3, surface tension and interfacial tension.